ROBO1 and SRGAP2

Number of citations of the paper that reports this interaction (PMID 11672528)
105

Data Source:
HPRD (two hybrid)

		ROBO1	SRGAP2
Gene Name		roundabout, axon guidance receptor, homolog 1 (Drosophila)	SLIT-ROBO Rho GTPase activating protein 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axolemma	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Lamellipodium Cell Junction Dendritic Spine Head Postsynaptic Membrane Phagocytic Vesicle
	Molecular Function	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding	Protein Binding Rac GTPase Activator Activity Protein Homodimerization Activity Rac GTPase Binding
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Roundabout Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Mammary Duct Terminal End Bud Growth Negative Regulation Of Chemokine-mediated Signaling Pathway	Lamellipodium Assembly Involved In Ameboidal Cell Migration Small GTPase Mediated Signal Transduction Axon Guidance Cell Proliferation Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Rac GTPase Activity Substrate Adhesion-dependent Cell Spreading Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Death Dendritic Spine Development Negative Regulation Of Neuron Migration
Pathways		Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Protein quantitative trait loci ( 18464913)	Cholesterol and Triglycerides ( 23031429)
Protein-Protein Interactions		8 interactors: ABL1 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3	5 interactors: DISC1 EXOC1 FASLG ROBO1 YWHAG
Entrez ID		6091	23380
HPRD ID		03890	18520
Ensembl ID		ENSG00000169855
Uniprot IDs		Q1RMC8 Q9Y6N7	A2RUF3 B4DFE5 B7Z3G4 B7ZM87 O75044
PDB IDs		2EO9 2V9Q 2V9R 2V9T	2DL8
Enriched GO Terms of Interacting Partners?		Chemotaxis Axon Guidance Cell Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Neuron Development Neuron Differentiation Cell Projection Organization Negative Regulation Of Locomotion Anatomical Structure Morphogenesis Regulation Of Locomotion Retinal Ganglion Cell Axon Guidance Generation Of Neurons Neurogenesis Negative Regulation Of Chemotaxis Cell Development Cell Differentiation Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Negative Regulation Of Cellular Component Movement Nervous System Development Dorsal/ventral Axon Guidance Luteolysis System Development Regulation Of Cellular Component Movement Developmental Growth Brain Development Regulation Of Cell Differentiation Head Development Developmental Cell Growth Multicellular Organismal Development Olfactory Bulb Interneuron Development Anatomical Structure Development Axon Extension Involved In Axon Guidance Central Nervous System Development Forebrain Development Developmental Process Olfactory Bulb Interneuron Differentiation Regulation Of Chemotaxis Growth Developmental Growth Involved In Morphogenesis	Positive Regulation Of Proteolysis Regulation Of Neuron Differentiation Cerebral Cortex Cell Migration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Death Telencephalon Cell Migration Forebrain Cell Migration Zymogen Activation Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Neurogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Negative Chemotaxis Regulation Of Cell Development Cerebral Cortex Development Roundabout Signaling Pathway Endosomal Lumen Acidification Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Pallium Development Regulation Of Cysteine-type Endopeptidase Activity Retinal Cell Programmed Cell Death Regulation Of Negative Chemotaxis Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Axon Midline Choice Point Recognition Negative Regulation Of Chemokine-mediated Signaling Pathway Protein Processing Necroptotic Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Axon Choice Point Recognition Mammary Duct Terminal End Bud Growth Positive Regulation Of Signal Transduction Organelle Organization Telencephalon Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Chloride Ion Homeostasis
Tagcloud ?		adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste	29a 29b 29c acp5 calcitonin calcr cd93 cdc42 commitment concert cytoskeletal gpr85 gtpase hypothesize mir monocytic multinucleated nfia osteoclast osteoclastic osteoclasts raw264 rnas robo slit sponge tartrate tempo transduced
Tagcloud (Difference) ?		adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste	29a 29b 29c acp5 calcitonin calcr cd93 cdc42 commitment concert cytoskeletal gpr85 gtpase hypothesize mir monocytic multinucleated nfia osteoclast osteoclastic osteoclasts raw264 rnas robo slit sponge tartrate tempo transduced
Tagcloud (Intersection) ?