ROBO1 and SRGAP1

Number of citations of the paper that reports this interaction (PMID 11672528)
105

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ROBO1	SRGAP1
Gene Name		roundabout, axon guidance receptor, homolog 1 (Drosophila)	SLIT-ROBO Rho GTPase activating protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axolemma	Cytoplasm Cytosol
	Molecular Function	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding	Protein Binding Rac GTPase Activator Activity Rac GTPase Binding
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Roundabout Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Mammary Duct Terminal End Bud Growth Negative Regulation Of Chemokine-mediated Signaling Pathway	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Rac GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Inactivation of Cdc42 and Rac Rho GTPase cycle Axon guidance Signaling by Rho GTPases Signaling by Robo receptor
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		8 interactors: ABL1 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3	5 interactors: BMPR1B CDC42 FASLG RHOA ROBO1
Entrez ID		6091	57522
HPRD ID		03890	09406
Ensembl ID		ENSG00000169855	ENSG00000196935
Uniprot IDs		Q1RMC8 Q9Y6N7	Q7Z6B7
PDB IDs		2EO9 2V9Q 2V9R 2V9T
Enriched GO Terms of Interacting Partners?		Chemotaxis Axon Guidance Cell Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Neuron Development Neuron Differentiation Cell Projection Organization Negative Regulation Of Locomotion Anatomical Structure Morphogenesis Regulation Of Locomotion Retinal Ganglion Cell Axon Guidance Generation Of Neurons Neurogenesis Negative Regulation Of Chemotaxis Cell Development Cell Differentiation Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Negative Regulation Of Cellular Component Movement Nervous System Development Dorsal/ventral Axon Guidance Luteolysis System Development Regulation Of Cellular Component Movement Developmental Growth Brain Development Regulation Of Cell Differentiation Head Development Developmental Cell Growth Multicellular Organismal Development Olfactory Bulb Interneuron Development Anatomical Structure Development Axon Extension Involved In Axon Guidance Central Nervous System Development Forebrain Development Developmental Process Olfactory Bulb Interneuron Differentiation Regulation Of Chemotaxis Growth Developmental Growth Involved In Morphogenesis	Axon Guidance Regulation Of Cell Proliferation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Positive Regulation Of Cell Death Neuron Projection Morphogenesis Cell Development Response To External Stimulus Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Differentiation Negative Chemotaxis Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Anatomical Structure Morphogenesis Neuron Development Organ Morphogenesis Positive Regulation Of Cell Projection Organization Cell Morphogenesis Regulation Of Signal Transduction Substantia Nigra Development Neuron Differentiation Positive Regulation Of Cytokinesis Cell Projection Organization Organ Development Locomotion Positive Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Neural Nucleus Development Sprouting Angiogenesis Regulation Of Cytokinesis Positive Regulation Of Neuron Apoptotic Process Cell Differentiation Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Growth Regulation Of Cell Death Generation Of Neurons Positive Regulation Of Cell Development Regulation Of Cell Differentiation Morphogenesis Of An Epithelium Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste
Tagcloud (Difference) ?		adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste
Tagcloud (Intersection) ?