ROBO1 and TUBB3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ROBO1	TUBB3
Gene Name		roundabout, axon guidance receptor, homolog 1 (Drosophila)	tubulin, beta 3 class III
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axolemma	Nucleus Cytoplasm Microtubule Axon Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Roundabout Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Mammary Duct Terminal End Bud Growth Negative Regulation Of Chemokine-mediated Signaling Pathway	Protein Folding Microtubule-based Process Mitotic Nuclear Division Axon Guidance Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Transmembrane Transport
Pathways		Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Epothilone D Epothilone B Ixabepilone
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		8 interactors: ABL1 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3	27 interactors: ANXA7 ARHGEF7 CAMSAP3 CDKN1A DDX39B EEF1G GABARAP GZMK HEXDC INSM1 KHDRBS1 LAPTM4A LIG1 MRPL28 MTCL1 PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE
Entrez ID		6091	10381
HPRD ID		03890	04044
Ensembl ID		ENSG00000169855	ENSG00000258947
Uniprot IDs		Q1RMC8 Q9Y6N7	A8K854 Q13509 Q53G92
PDB IDs		2EO9 2V9Q 2V9R 2V9T
Enriched GO Terms of Interacting Partners?		Chemotaxis Axon Guidance Cell Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Neuron Development Neuron Differentiation Cell Projection Organization Negative Regulation Of Locomotion Anatomical Structure Morphogenesis Regulation Of Locomotion Retinal Ganglion Cell Axon Guidance Generation Of Neurons Neurogenesis Negative Regulation Of Chemotaxis Cell Development Cell Differentiation Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Negative Regulation Of Cellular Component Movement Nervous System Development Dorsal/ventral Axon Guidance Luteolysis System Development Regulation Of Cellular Component Movement Developmental Growth Brain Development Regulation Of Cell Differentiation Head Development Developmental Cell Growth Multicellular Organismal Development Olfactory Bulb Interneuron Development Anatomical Structure Development Axon Extension Involved In Axon Guidance Central Nervous System Development Forebrain Development Developmental Process Olfactory Bulb Interneuron Differentiation Regulation Of Chemotaxis Growth Developmental Growth Involved In Morphogenesis	Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Mitotic Cell Cycle Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Cell Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Division Cell Cycle Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Response To Toxic Substance Negative Regulation Of Chromosome Segregation Cell Division Cytoskeleton Organization Microtubule Bundle Formation Positive Regulation Of Microtubule Motor Activity Fetal Process Involved In Parturition Columnar/cuboidal Epithelial Cell Development Regulation Of DNA Biosynthetic Process Microtubule-based Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Epithelial Cell Development Regulation Of Cell Morphogenesis Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Spliceosomal Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tyms vegfr2
Tagcloud (Difference) ?		adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 repressive rho rock1 roundabout silencing suz12 tri zeste	actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tyms vegfr2
Tagcloud (Intersection) ?		qrt