ROBO1 and SLIT1

Number of citations of the paper that reports this interaction (PMID 10433822)
56

Data Source:
HPRD (in vivo)

		ROBO1	SLIT1
Gene Name		roundabout, axon guidance receptor, homolog 1 (Drosophila)	slit homolog 1 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axolemma	Extracellular Space
	Molecular Function	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding	Calcium Ion Binding Heparan Sulfate Proteoglycan Binding Roundabout Binding
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Roundabout Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Mammary Duct Terminal End Bud Growth Negative Regulation Of Chemokine-mediated Signaling Pathway	Axon Guidance Motor Neuron Axon Guidance Spinal Cord Development Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Retinal Ganglion Cell Axon Guidance Dorsal/ventral Axon Guidance Establishment Of Nucleus Localization Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Forebrain Morphogenesis Negative Chemotaxis Negative Regulation Of Synapse Assembly
Pathways		Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor	Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Protein quantitative trait loci ( 18464913)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: ABL1 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3	3 interactors: ATN1 GPC1 ROBO1
Entrez ID		6091	6585
HPRD ID		03890	04773
Ensembl ID		ENSG00000169855	ENSG00000187122
Uniprot IDs		Q1RMC8 Q9Y6N7	A6H8V1 O75093
PDB IDs		2EO9 2V9Q 2V9R 2V9T
Enriched GO Terms of Interacting Partners?		Chemotaxis Axon Guidance Cell Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Neuron Development Neuron Differentiation Cell Projection Organization Negative Regulation Of Locomotion Anatomical Structure Morphogenesis Regulation Of Locomotion Retinal Ganglion Cell Axon Guidance Generation Of Neurons Neurogenesis Negative Regulation Of Chemotaxis Cell Development Cell Differentiation Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Negative Regulation Of Cellular Component Movement Nervous System Development Dorsal/ventral Axon Guidance Luteolysis System Development Regulation Of Cellular Component Movement Developmental Growth Brain Development Regulation Of Cell Differentiation Head Development Developmental Cell Growth Multicellular Organismal Development Olfactory Bulb Interneuron Development Anatomical Structure Development Axon Extension Involved In Axon Guidance Central Nervous System Development Forebrain Development Developmental Process Olfactory Bulb Interneuron Differentiation Regulation Of Chemotaxis Growth Developmental Growth Involved In Morphogenesis	Locomotion Heparan Sulfate Proteoglycan Catabolic Process Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Negative Chemotaxis Movement Of Cell Or Subcellular Component Proteoglycan Catabolic Process Roundabout Signaling Pathway Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Mammary Duct Terminal End Bud Growth Axon Choice Point Recognition Axon Guidance Tangential Migration From The Subventricular Zone To The Olfactory Bulb Nervous System Development Olfactory Bulb Interneuron Development Positive Regulation Of Skeletal Muscle Cell Differentiation Maintenance Of Cell Polarity Axonogenesis Glycoprotein Catabolic Process Toxin Metabolic Process Cerebral Cortex Tangential Migration Axon Development Cell Morphogenesis Involved In Neuron Differentiation Olfactory Bulb Interneuron Differentiation Chemotaxis Neuron Projection Morphogenesis Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Skeletal Muscle Cell Differentiation Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Negative Regulation Of Chemotaxis Neuron Projection Development Positive Regulation Of Skeletal Muscle Tissue Development Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Myelin Assembly Blood Vessel Endothelial Cell Migration Cell Motility Heparan Sulfate Proteoglycan Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Neuron Recognition Negative Regulation Of Cytokine-mediated Signaling Pathway Neuron Development
Tagcloud ?		adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste	attractant attractants attractively away axons connect constrain dcc explant explanted fasciculus grow longitudinal longitudinally midline navigation netrin netrin1 pioneer positioned pull push repellents repulsive robo slit2 trajectories ventrally
Tagcloud (Difference) ?		adjacent altogether anomalously coil coiled di e2f1 evidences generating great h3k27me3 homolog metastasis noncancerous nsclc oncogene paired partly polycomb prc2 qrt repressive rho rock1 roundabout silencing suz12 tri zeste	attractant attractants attractively away axons connect constrain dcc explant explanted fasciculus grow longitudinal longitudinally midline navigation netrin netrin1 pioneer positioned pull push repellents repulsive robo slit2 trajectories ventrally
Tagcloud (Intersection) ?