HRK and C1QBP

Number of citations: 0 (PubMedID 15031724)
Data Source: HPRD (two hybrid, in vitro)

		HRK	C1QBP
Name		harakiri, BCL2 interacting protein	complement C1q binding protein
Structure
GO Annotations	Cellular Component	Mitochondrion Membrane	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding	Complement Component C1q Complex Binding Transcription Corepressor Activity MRNA Binding Enzyme Inhibitor Activity Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Kininogen Binding Adrenergic Receptor Binding Deoxyribonuclease Inhibitor Activity C5-methylcytidine-containing RNA Reader Activity Mitochondrial Ribosome Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Potassium Ion Starvation Positive Regulation Of Release Of Cytochrome C From Mitochondria	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Mitochondrial RNA Catabolic Process Adaptive Immune Response Immune System Process MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway DNA Damage Response RNA Splicing Regulation Of Complement Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Ribosome Biogenesis Cytosolic Ribosome Assembly Positive Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		None	Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation RHOA GTPase cycle RHOC GTPase cycle Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Drugs		None	Hyaluronic acid Copper
GWAS		Alzheimer's disease (age of onset) ( 22005931 ) Brain morphology (MOSTest) ( 32665545 ) Brain structure ( 22504417 ) Dentate gyrus granule cell layer volume ( 30279459 ) Dentate gyrus molecular layer volume ( 30279459 ) HATA volume ( 30279459 ) Hippocampal subfield CA1 volume ( 30279459 ) Hippocampal subfield CA3 volume ( 30279459 ) Hippocampal subfield CA4 volume ( 30279459 ) Hippocampal tail volume ( 30279459 ) Hippocampal volume ( 28098162 22504421 ) Presubiculum volume ( 30279459 ) Presubiculum volume (corrected for total hippocampal volume) ( 30279459 ) Subcortical brain region volumes ( 25607358 ) Subiculum volume ( 30279459 ) Total hippocampal volume ( 30279459 )	Rheumatoid arthritis ( 24390342 30423114 )
Interacting Genes		7 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1	105 interacting genes: C1QA CDK13 CEBPA COIL DUX4 EXOSC6 FOXP1 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK KLF1 MAPK1 MAPK3 MBD1 MBD2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SHANK3 SRSF1 SRSF9 TOP3B ULK1 YWHAB YWHAG
Entrez ID		8739	708
HPRD ID		04581	03168
Ensembl ID		ENSG00000135116	ENSG00000108561
Uniprot IDs		O00198	Q07021
PDB IDs		2L58 2L5B 6XY4 7P0U	1P32 3RPX 6SZW 7TE3
GO Terms Enriched among Interactors		Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway Channel Activity Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Process Mitochondrion Organization Positive Regulation Of Programmed Cell Death BH3 Domain Binding Apoptotic Signaling Pathway DNA Damage Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Death Programmed Cell Death Negative Regulation Of Anoikis Intracellular Signal Transduction BAD-BCL-2 Complex Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Dendritic Cell Apoptotic Process Epithelial Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Stress Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Dendritic Cell Apoptotic Process Cell Population Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Autophagy Mitochondrial Membrane Organization Regulation Of Autophagy Regulation Of Apoptotic Signaling Pathway Organelle Organization Mitochondrial Fusion Mitochondrion Hematopoietic Stem Cell Differentiation Programmed Cell Death Involved In Cell Development Regulation Of Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Regulation Of Cellular Response To Stress	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Vasculature Development Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Developmental Process Regulation Of Locomotion Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Developmental Process Negative Regulation Of Blood Vessel Endothelial Cell Migration