HRK and C1QBP

Number of citations of the paper that reports this interaction (PMID 15031724)
17

Data Source:
HPRD (two hybrid, in vitro)

		HRK	C1QBP
Gene Name		harakiri, BCL2 interacting protein	complement component 1, q subcomponent binding protein
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Integral Component Of Membrane	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding	Complement Component C1q Binding Transcription Corepressor Activity MRNA Binding Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Kininogen Binding Adrenergic Receptor Binding Mitochondrial Ribosome Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein Homooligomerization Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway RNA Splicing Phosphatidylinositol 3-kinase Signaling Viral Process Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways			Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Brain structure ( 22504417) Hippocampal volume ( 22504421)
Protein-Protein Interactions		7 interactors: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1	24 interactors: C1QA CEBPA COIL EXOSC6 GAB1 GABRB1 HABP4 HNRNPD HRK MAPK1 MAPK3 MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SRSF1 SRSF9 TOP3B YWHAB YWHAG
Entrez ID		8739	708
HPRD ID		04581	03168
Ensembl ID			ENSG00000108561
Uniprot IDs		O00198	Q07021
PDB IDs		2L58 2L5B	1P32 3RPX
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Anoikis Regulation Of Mitochondrion Organization Regulation Of Anoikis Regulation Of Intracellular Signal Transduction Cellular Response To DNA Damage Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Release Of Cytochrome C From Mitochondria Negative Regulation Of Signal Transduction Suppression By Virus Of Host Apoptotic Process Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Signaling Regulation Of Membrane Permeability Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Cellular Response To Stress Positive Regulation Of Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Organization Cellular Process Regulating Host Cell Cycle In Response To Virus Regulation Of Signaling Regulation Of Neuron Death Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrion Organization Regulation Of Autophagy	Vascular Endothelial Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Response To Fibroblast Growth Factor Cellular Response To Insulin Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Defense Response Cellular Response To Organonitrogen Compound Regulation Of Protein Kinase Activity Response To Insulin Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Regulation Of Kinase Activity Cellular Response To Peptide Innate Immune Response Response To Organonitrogen Compound Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade Immune Response Regulation Of Phosphorylation Response To Hormone Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Response To Peptide Hormone Cell Death Death Regulation Of Phosphorus Metabolic Process
Tagcloud ?		a280 acidic adsorptions ahraa amidase amidases amidolysis aprotinin arginine bean bis column daltons differing egta elution elutions ethylenglycol ethylether kallikrein lbti leu lima named pna tentatively tetraacetic trypsin val	133a a2m affymetrix afzelii borrelia burgdorferii burgeforii c1s cd46 cd59 cfb cfh complement cultivation defence differentiates diploid fhl1 garinii genospecies hgu launch penetrating sensu spirochaete spirochaetes stricto transcriptomes vsig4
Tagcloud (Difference) ?		a280 acidic adsorptions ahraa amidase amidases amidolysis aprotinin arginine bean bis column daltons differing egta elution elutions ethylenglycol ethylether kallikrein lbti leu lima named pna tentatively tetraacetic trypsin val	133a a2m affymetrix afzelii borrelia burgdorferii burgeforii c1s cd46 cd59 cfb cfh complement cultivation defence differentiates diploid fhl1 garinii genospecies hgu launch penetrating sensu spirochaete spirochaetes stricto transcriptomes vsig4
Tagcloud (Intersection) ?