HRK and BCL2L2

Number of citations of the paper that reports this interaction (PMID 15694340)
428

Data Source:
BioGRID (unspecified method)
HPRD (in vitro)

		HRK	BCL2L2
Gene Name		harakiri, BCL2 interacting protein	BCL2-like 2
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Integral Component Of Membrane	Mitochondrial Outer Membrane Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH Domain Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein Homooligomerization Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Brain structure ( 22504417) Hippocampal volume ( 22504421)
Protein-Protein Interactions		7 interactors: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1	14 interactors: BAD BAK1 BBC3 BCL2L11 BID BIK BMF CCDC155 FATE1 HRK PMAIP1 PPP1CA TCF4 TP53
Entrez ID		8739	599
HPRD ID		04581	03569
Ensembl ID			ENSG00000129473
Uniprot IDs		O00198	Q92843
PDB IDs		2L58 2L5B	1MK3 1O0L 1ZY3 2Y6W
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Anoikis Regulation Of Mitochondrion Organization Regulation Of Anoikis Regulation Of Intracellular Signal Transduction Cellular Response To DNA Damage Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Release Of Cytochrome C From Mitochondria Negative Regulation Of Signal Transduction Suppression By Virus Of Host Apoptotic Process Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Signaling Regulation Of Membrane Permeability Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Cellular Response To Stress Positive Regulation Of Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Organization Cellular Process Regulating Host Cell Cycle In Response To Virus Regulation Of Signaling Regulation Of Neuron Death Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrion Organization Regulation Of Autophagy	Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Signal Transduction Regulation Of Membrane Permeability Positive Regulation Of Protein Complex Assembly Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Intracellular Transport Mitochondrial Membrane Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Complex Assembly Regulation Of Organelle Organization Apoptotic Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity Mitochondrion Organization Cell Death Death Zymogen Activation Positive Regulation Of Transport Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Cellular Component Organization Regulation Of Signal Transduction Mitochondrial Transport Positive Regulation Of Neuron Death Regulation Of Signaling
Tagcloud ?		a280 acidic adsorptions ahraa amidase amidases amidolysis aprotinin arginine bean bis column daltons differing egta elution elutions ethylenglycol ethylether kallikrein lbti leu lima named pna tentatively tetraacetic trypsin val	bag1 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?		a280 acidic adsorptions ahraa amidase amidases amidolysis aprotinin arginine bean bis column daltons differing egta elution elutions ethylenglycol ethylether kallikrein lbti leu lima named pna tentatively tetraacetic trypsin val	bag1 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Intersection) ?