HRK and BCL2L2

Number of citations of the paper that reports this interaction (PubMedID 15694340)
0

Data Source:
BioGRID (unspecified method)
HPRD (in vitro)

		HRK	BCL2L2
Description		harakiri, BCL2 interacting protein	BCL2 like 2
Image
GO Annotations	Cellular Component	Mitochondrion Membrane	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Bcl-2 Family Protein Complex
	Molecular Function	Protein Binding	Protein Binding Channel Activity Identical Protein Binding Disordered Domain Specific Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Potassium Ion Starvation Positive Regulation Of Release Of Cytochrome C From Mitochondria	Release Of Cytochrome C From Mitochondria Developmental Process Involved In Reproduction Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs			Navitoclax
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Brain morphology (MOSTest) ( 32665545) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Hippocampal volume ( 28098162 22504421) Presubiculum volume ( 30279459) Presubiculum volume (corrected for total hippocampal volume) ( 30279459) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)	Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1	53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CEBPA CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35E3 SLC35H1 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53
Entrez ID		8739	599
HPRD ID		04581	03569
Ensembl ID		ENSG00000135116	ENSG00000129473
Uniprot IDs		O00198	Q92843
PDB IDs		2L58 2L5B 6XY4 7P0U	1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?		Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway Channel Activity Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Process Mitochondrion Organization Positive Regulation Of Programmed Cell Death BH3 Domain Binding Apoptotic Signaling Pathway DNA Damage Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Death Programmed Cell Death Negative Regulation Of Anoikis Intracellular Signal Transduction BAD-BCL-2 Complex Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Dendritic Cell Apoptotic Process Epithelial Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Stress Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Dendritic Cell Apoptotic Process Cell Population Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Autophagy Mitochondrial Membrane Organization Regulation Of Autophagy Regulation Of Apoptotic Signaling Pathway Organelle Organization Mitochondrial Fusion Mitochondrion Hematopoietic Stem Cell Differentiation Programmed Cell Death Involved In Cell Development Regulation Of Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Regulation Of Cellular Response To Stress	Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Apoptotic Mitochondrial Changes Apoptotic Process Positive Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Cell Death Positive Regulation Of Programmed Cell Death Programmed Cell Death Mitochondrial Outer Membrane Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Signaling Pathway Regulation Of Membrane Permeability Mitochondrion Organization Cellular Response To Stress Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein-containing Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Fibroblast Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway T Cell Apoptotic Process Bcl-2 Family Protein Complex Positive Regulation Of Organelle Organization Positive Regulation Of Fibroblast Apoptotic Process Cellular Response To Hypoxia Lymphocyte Apoptotic Process Thymocyte Apoptotic Process Cellular Response To Decreased Oxygen Levels Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Triglyceride Metabolic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxygen Levels Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Identical Protein Binding Leukocyte Apoptotic Process Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrion Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
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