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BAK1 and BCL2L1
Number of citations of the paper that reports this interaction (PubMedID
15901672
)
60
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, in vitro)
BAK1
BCL2L1
Description
BCL2 antagonist/killer 1
BCL2 like 1
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Cytosol
Membrane
Mitochondrial Membrane
Pore Complex
Bcl-2 Family Protein Complex
BAK Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Endoplasmic Reticulum
Centrosome
Cytosol
Cytoskeleton
Membrane
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Nuclear Membrane
Mitochondrial Membrane
Synapse
Bcl-2 Family Protein Complex
Molecular Function
Protein Binding
Channel Activity
Porin Activity
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Transmembrane Transporter Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Protein-folding Chaperone Binding
BH Domain Binding
Protein Binding
Channel Activity
Protein Kinase Binding
Identical Protein Binding
BH3 Domain Binding
Biological Process
Leukocyte Homeostasis
B Cell Homeostasis
B Cell Apoptotic Process
Release Of Cytochrome C From Mitochondria
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
Apoptotic Process
Mitochondrial Fusion
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Response To Fungus
Response To Mycotoxin
Response To UV-C
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Gene Expression
Endocrine Pancreas Development
Animal Organ Regeneration
Positive Regulation Of Protein-containing Complex Assembly
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Monoatomic Ion Transmembrane Transport
Cellular Response To Unfolded Protein
Cellular Response To UV
Limb Morphogenesis
Response To Hydrogen Peroxide
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Fibroblast Apoptotic Process
Response To Ethanol
Positive Regulation Of Proteolysis
Regulation Of Mitochondrial Membrane Permeability
Post-embryonic Camera-type Eye Morphogenesis
Homeostasis Of Number Of Cells
Epithelial Cell Proliferation
Regulation Of Transport
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Regulation Of Mitochondrial Membrane Potential
Vagina Development
Calcium Ion Transport Into Cytosol
Regulation Of Biological Quality
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Cellular Response To Mechanical Stimulus
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process Involved In Blood Vessel Morphogenesis
Regulation Of Intracellular Signal Transduction
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of Apoptotic Signaling Pathway
Ovarian Follicle Development
In Utero Embryonic Development
Release Of Cytochrome C From Mitochondria
Endocytosis
Apoptotic Process
Response To Stress
Mitochondrion Organization
Germ Cell Development
Spermatogenesis
Male Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Apoptotic Mitochondrial Changes
Response To Radiation
Fertilization
Response To Virus
Negative Regulation Of Autophagy
Regulation Of Cytokinesis
Positive Regulation Of Mononuclear Cell Proliferation
Response To Cytokine
Ectopic Germ Cell Programmed Cell Death
Regulation Of Growth
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Dendritic Cell Proliferation
Response To Cycloheximide
Regulation Of Mitochondrial Membrane Permeability
Epithelial Cell Proliferation
Negative Regulation Of Developmental Process
Neuron Apoptotic Process
Defense Response To Virus
Response To Other Organism
Regulation Of Mitochondrial Membrane Potential
Transmembrane Transport
Cellular Response To Amino Acid Stimulus
Cellular Response To Alkaloid
Cellular Response To Gamma Radiation
Apoptotic Process In Bone Marrow Cell
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Dendritic Cell Apoptotic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Hepatocyte Apoptotic Process
Negative Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Reproductive Process
Negative Regulation Of Dendritic Cell Apoptotic Process
Negative Regulation Of Anoikis
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Activation and oligomerization of BAK protein
Release of apoptotic factors from the mitochondria
Pyroptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-4 and Interleukin-13 signaling
The NLRP1 inflammasome
RAS processing
SARS-CoV-1-mediated effects on programmed cell death
STAT5 activation downstream of FLT3 ITD mutants
NFE2L2 regulating tumorigenic genes
Drugs
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
Gossypol
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) (
28112199
)
Body mass index (
26426971
)
Chronic lymphocytic leukemia (
24292274
28165464
23770605
22700719
)
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
27841878
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Hematological parameters (
19820697
)
Lung cancer (
28604730
)
Multiple sclerosis and systolic blood pressure (pleiotropy) (
26920376
)
Neutrophil percentage of granulocytes (
27863252
)
Obesity-related traits (
23251661
)
Platelet count (
29066854
27863252
29403010
32888494
33545615
28031487
20139978
26805783
25705162
24026423
22139419
22423221
23263863
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Schizophrenia (
30285260
)
Spleen volume (
34128465
)
Sum eosinophil basophil counts (
27863252
)
Testicular germ cell tumor (
23666239
23666240
28604732
28604728
19483681
)
Brain morphology (MOSTest) (
32665545
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
27863252
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder (
26184070
)
Platelet count (
27863252
32888494
)
Plateletcrit (
27863252
32888494
)
Prudent dietary pattern (
28644415
)
Putamen volume (
29147026
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
20 interacting genes:
ARHGDIA
BAX
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BID
DBN1
ERN1
HERC1
HSD17B4
HSPD1
MCL1
MFN1
NFKBIB
TP53
UBE3A
VDAC1
VDAC2
111 interacting genes:
ACTB
AKT1
ANTXR1
APAF1
AURKA
AVEN
BAD
BAG1
BAK1
BAX
BBC3
BCAP31
BCL2
BCL2L10
BCL2L11
BCL2L12
BCL2L14
BCLAF1
BECN1
BID
BIK
BLK
BMF
BNIP1
BNIP3
BNIP3L
BNIP5
BNIPL
C10orf67
CAPN1
CASP1
CASP8
CASP9
CDKN2A
CFLAR
CHEK1
CREB3
CRYAA
CRYAB
CYCS
DOCK7
EDRF1
ELOVL4
ERGIC3
FBP1
FKBP8
G0S2
GLOD4
GNLY
GOLM1
GORAB
GSK3A
GSK3B
HNRNPA1
HRK
IKZF3
IRS1
IRS2
LARP1
MAPK14
MAPK8
MAPK9
MAPKAPK2
MCL1
METTL23
MOAP1
MTIF3
MTNR1B
MTOR
NLRP1
PARK7
PDIA4
PINK1
PLD3
PLK1
PLK3
PMAIP1
PPHLN1
PPP1CA
PRKN
PSEN1
PSEN2
PTN
RAD9A
RAF1
RBM5
REEP4
RHBDD2
RIC3
RNF183
RNF4
RTN1
RTN4
RYR3
SIVA1
SNCA
SPNS1
TLE1
TMBIM6
TMEM50B
TP53
TP53BP2
TPT1
UBE2I
UBR1
UHRF2
VAC14
VDAC1
ZFYVE1
ZHX1
ZNF219
Entrez ID
578
598
HPRD ID
02744
02497
Ensembl ID
ENSG00000030110
ENSG00000171552
Uniprot IDs
A0A0S2Z391
Q16611
A0A0S2Z3C5
Q07817
Q5TE63
PDB IDs
1BXL
2IMS
2IMT
2JBY
2JCN
2LP8
2M5B
2XPX
2YV6
3I1H
3QBR
4D2L
4U2U
4U2V
4UF1
5AJK
5FMI
5FMK
5VWV
5VWW
5VWX
5VWY
5VWZ
5VX0
5VX1
6ODH
6UXM
6UXN
6UXO
6UXP
6UXQ
6UXR
7K02
7LK4
7M5A
7M5B
7OFM
7OFO
8CZF
8CZG
8CZH
8GSV
8IGC
8IVB
8SRX
8SRY
8UKY
8Y1Y
8Y1Z
1BXL
1G5J
1LXL
1MAZ
1R2D
1R2E
1R2G
1R2H
1R2I
1YSG
1YSI
1YSN
2B48
2LP8
2LPC
2M03
2M04
2ME8
2ME9
2MEJ
2O1Y
2O2M
2O2N
2P1L
2PON
2YJ1
2YQ6
2YQ7
2YXJ
3CVA
3FDL
3FDM
3INQ
3IO8
3PL7
3QKD
3R85
3SP7
3SPF
3WIZ
3ZK6
3ZLN
3ZLO
3ZLR
4A1U
4A1W
4AQ3
4BPK
4C52
4C5D
4CIN
4EHR
4HNJ
4IEH
4PPI
4QVE
4QVF
4QVX
4TUH
4Z9V
5AGW
5AGX
5B1Z
5C3G
5FMJ
5FMK
5VAY
5VX3
6BF2
6DCN
6DCO
6F46
6HJL
6IJQ
6LHD
6O0K
6O0L
6O0M
6O0O
6O0P
6RNU
6ST2
6UVC
6UVD
6UVE
6UVF
6UVG
6UVH
6VWC
6X7I
6YLI
6ZHC
7CA4
7JGV
7JGW
7LH7
7XGF
7XGG
7Y8D
7YAA
8FY0
8IQK
8IQL
8U27
8VWX
8VWZ
8VXM
8VXN
8WLS
8XP5
8ZEB
9AQZ
Enriched GO Terms of Interacting Partners
?
Apoptotic Mitochondrial Changes
Release Of Cytochrome C From Mitochondria
Mitochondrion Organization
Mitochondrial Outer Membrane
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Channel Activity
Bcl-2 Family Protein Complex
Intrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
BH3 Domain Binding
Negative Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Programmed Cell Death
Regulation Of Membrane Permeability
Pore Complex
Apoptotic Process
Mitochondrial Membrane
Programmed Cell Death
Cell Death
Mitochondrial Membrane Organization
Mitochondrion
Mitochondrial Fusion
Regulation Of Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Regulation Of Mitochondrial Membrane Potential
Regulation Of Programmed Cell Death
Positive Regulation Of Mitochondrial Membrane Permeability
Cellular Response To Stress
Positive Regulation Of Membrane Permeability
Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Regulation Of Intrinsic Apoptotic Signaling Pathway
DNA Damage Response
Negative Regulation Of Autophagy
Intracellular Signal Transduction
Neuron Apoptotic Process
Regulation Of Autophagy
Regulation Of Release Of Cytochrome C From Mitochondria
Transmembrane Transport
Epithelial Cell Apoptotic Process
Ovarian Follicle Development
Mononuclear Cell Proliferation
Leukocyte Apoptotic Process
Response To Gamma Radiation
Leukocyte Proliferation
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Programmed Cell Death
Cell Death
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Cellular Response To Stress
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Programmed Cell Death
Regulation Of Mitochondrion Organization
Negative Regulation Of Apoptotic Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Apoptotic Mitochondrial Changes
Mitochondrion Organization
Mitochondrial Outer Membrane
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Response To Stress
Mitochondrion
Regulation Of Cellular Response To Stress
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Membrane Permeability
Regulation Of Mitochondrial Membrane Permeability
Extrinsic Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Regulation Of Autophagy
Mitochondrial Membrane Organization
Positive Regulation Of Mitochondrial Membrane Permeability
Positive Regulation Of Organelle Organization
Regulation Of Signal Transduction
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Membrane Permeability
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Bcl-2 Family Protein Complex
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Mitochondrial Membrane Potential
Regulation Of Signaling
Regulation Of Cell Communication
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Response To Decreased Oxygen Levels
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Protein-containing Complex Assembly
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Tagcloud (Intersection)
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