BAK1 and ARHGDIA

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		BAK1	ARHGDIA
Description		BCL2 antagonist/killer 1	Rho GDP dissociation inhibitor alpha
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Membrane Mitochondrial Membrane Pore Complex Bcl-2 Family Protein Complex BAK Complex	Immunological Synapse Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Binding Channel Activity Porin Activity Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding BH Domain Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Leukocyte Homeostasis B Cell Homeostasis B Cell Apoptotic Process Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection Apoptotic Process Mitochondrial Fusion Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Response To Fungus Response To Mycotoxin Response To UV-C Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Endocrine Pancreas Development Animal Organ Regeneration Positive Regulation Of Protein-containing Complex Assembly Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Monoatomic Ion Transmembrane Transport Cellular Response To Unfolded Protein Cellular Response To UV Limb Morphogenesis Response To Hydrogen Peroxide Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Fibroblast Apoptotic Process Response To Ethanol Positive Regulation Of Proteolysis Regulation Of Mitochondrial Membrane Permeability Post-embryonic Camera-type Eye Morphogenesis Homeostasis Of Number Of Cells Epithelial Cell Proliferation Regulation Of Transport Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Vagina Development Calcium Ion Transport Into Cytosol Regulation Of Biological Quality Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Blood Vessel Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Apoptotic Signaling Pathway	Rho Protein Signal Transduction Regulation Of Protein Localization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Semaphorin-plexin Signaling Pathway Regulation Of Synaptic Vesicle Cycle
Pathways		Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria Pyroptosis	Axonal growth inhibition (RHOA activation) Axonal growth stimulation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Chronic lymphocytic leukemia ( 24292274 28165464 23770605 22700719) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Hematological parameters ( 19820697) Lung cancer ( 28604730) Multiple sclerosis and systolic blood pressure (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Platelet count ( 29066854 27863252 29403010 32888494 33545615 28031487 20139978 26805783 25705162 24026423 22139419 22423221 23263863) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Schizophrenia ( 30285260) Spleen volume ( 34128465) Sum eosinophil basophil counts ( 27863252) Testicular germ cell tumor ( 23666239 23666240 28604732 28604728 19483681)
Interacting Genes		20 interacting genes: ARHGDIA BAX BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BID DBN1 ERN1 HERC1 HSD17B4 HSPD1 MCL1 MFN1 NFKBIB TP53 UBE3A VDAC1 VDAC2	41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B CEBPA EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		578	396
HPRD ID		02744	03565
Ensembl ID		ENSG00000030110	ENSG00000141522
Uniprot IDs		A0A0S2Z391 Q16611	J3QQX2 P52565 V9HWE8
PDB IDs		1BXL 2IMS 2IMT 2JBY 2JCN 2LP8 2M5B 2XPX 2YV6 3I1H 3QBR 4D2L 4U2U 4U2V 4UF1 5AJK 5FMI 5FMK 5VWV 5VWW 5VWX 5VWY 5VWZ 5VX0 5VX1 6ODH 6UXM 6UXN 6UXO 6UXP 6UXQ 6UXR 7K02 7LK4 7M5A 7M5B 7OFM 7OFO 8CZF 8CZG 8CZH 8GSV 8IGC 8IVB 8SRX 8SRY 8UKY 8Y1Y 8Y1Z	1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80 8X8T
Enriched GO Terms of Interacting Partners?		Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Mitochondrion Organization Mitochondrial Outer Membrane Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Channel Activity Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death BH3 Domain Binding Negative Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Programmed Cell Death Regulation Of Membrane Permeability Pore Complex Apoptotic Process Mitochondrial Membrane Programmed Cell Death Cell Death Mitochondrial Membrane Organization Mitochondrion Mitochondrial Fusion Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Mitochondrial Membrane Potential Regulation Of Programmed Cell Death Positive Regulation Of Mitochondrial Membrane Permeability Cellular Response To Stress Positive Regulation Of Membrane Permeability Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Intrinsic Apoptotic Signaling Pathway DNA Damage Response Negative Regulation Of Autophagy Intracellular Signal Transduction Neuron Apoptotic Process Regulation Of Autophagy Regulation Of Release Of Cytochrome C From Mitochondria Transmembrane Transport Epithelial Cell Apoptotic Process Ovarian Follicle Development Mononuclear Cell Proliferation Leukocyte Apoptotic Process Response To Gamma Radiation Leukocyte Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process	Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Negative Regulation Of Cellular Component Organization Cellular Response To Stress Erythrocyte Enucleation Regulation Of Primary Metabolic Process Actin Filament Organization Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Shelterin Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cytoskeleton Organization Post-translational Protein Modification Response To Stress Positive Regulation Of Metabolic Process Protein Modification Process Macromolecule Catabolic Process Positive Regulation Of Lamellipodium Assembly Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Developmental Process Negative Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Nuclear Telomere Cap Complex Positive Regulation Of Developmental Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Lamellipodium Assembly Fibroblast Apoptotic Process Positive Regulation Of Cell Adhesion Regulation Of Macromolecule Biosynthetic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament-based Process Telomere Capping Regulation Of Metabolic Process Small GTPase-mediated Signal Transduction Regulation Of Cell Projection Organization Proteolysis Involved In Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Intracellular Signaling Cassette
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