BBC3

Gene Name		BCL2 binding component 3
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Protein Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Determination Of Adult Lifespan Positive Regulation Of Protein Homooligomerization Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Growth Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of PUMA and translocation to mitochondria Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 MCL1
Entrez ID		27113
HPRD ID		16165
Ensembl ID		ENSG00000105327
Uniprot IDs		Q96PG8 Q9BXH1
PDB IDs		2M04 4HNJ
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To DNA Damage Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Anoikis Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Regulation Of Anoikis Cell Death Death Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Male Gonad Development Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Potential Male Sex Differentiation Regulation Of Mitochondrial Membrane Permeability Regulation Of Apoptotic Process Regulation Of Membrane Permeability Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Stress Regulation Of Cell Death Gonad Development Development Of Primary Sexual Characteristics Regulation Of Nitrogen Utilization Regulation Of Neuron Apoptotic Process Response To Gamma Radiation Regulation Of Intracellular Signal Transduction Neuron Apoptotic Process Intracellular Signal Transduction Sertoli Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Sex Differentiation Regulation Of Neuron Death Mitochondrial Membrane Organization Neuron Death Ovarian Follicle Development
Tagcloud ?		abrogated abundance antiapoptotic barely bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing