BBC3 and BCL2L1

Number of citations of the paper that reports this interaction (PMID 15694340)
428

Data Source:
HPRD (two hybrid, in vitro)

		BBC3	BCL2L1
Gene Name		BCL2 binding component 3	BCL2-like 1
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Centrosome Cytosol Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Nuclear Membrane Bcl-2 Family Protein Complex
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Determination Of Adult Lifespan Positive Regulation Of Protein Homooligomerization Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Growth Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cytokinesis Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Apoptotic Process Mitotic Cell Cycle Checkpoint Germ Cell Development Spermatogenesis Cell Proliferation Positive Regulation Of Cell Proliferation Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Negative Regulation Of Autophagy Suppression By Virus Of Host Apoptotic Process Response To Cytokine Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Cellular Process Regulating Host Cell Cycle In Response To Virus Mitochondrion Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of PUMA and translocation to mitochondria Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis	Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 MCL1	79 interactors: ACTB AKT1 ANTXR1 APAF1 AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIPL CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CRYAA CRYAB CYCS DOCK7 EDRF1 FBP1 FKBP8 GLOD4 HRK IKZF3 IRS1 IRS2 LARP1 MAPK8 MCL1 METTL23 MOAP1 MTOR NLRP1 PARK7 PDIA4 PLD3 PMAIP1 PPHLN1 PPP1CA PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 RTN1 RTN4 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TP53 TP53BP2 TPT1 UBR1 UHRF2 VDAC1 ZFYVE1 ZHX1 ZNF219
Entrez ID		27113	598
HPRD ID		16165	02497
Ensembl ID		ENSG00000105327	ENSG00000171552
Uniprot IDs		Q96PG8 Q9BXH1	Q07817 Q5TE63
PDB IDs		2M04 4HNJ	1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4EHR 4HNJ 4IEH
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To DNA Damage Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Anoikis Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Regulation Of Anoikis Cell Death Death Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Male Gonad Development Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Potential Male Sex Differentiation Regulation Of Mitochondrial Membrane Permeability Regulation Of Apoptotic Process Regulation Of Membrane Permeability Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Stress Regulation Of Cell Death Gonad Development Development Of Primary Sexual Characteristics Regulation Of Nitrogen Utilization Regulation Of Neuron Apoptotic Process Response To Gamma Radiation Regulation Of Intracellular Signal Transduction Neuron Apoptotic Process Intracellular Signal Transduction Sertoli Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Sex Differentiation Regulation Of Neuron Death Mitochondrial Membrane Organization Neuron Death Ovarian Follicle Development	Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrion Organization Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endopeptidase Activity Zymogen Activation Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Negative Regulation Of Programmed Cell Death Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Peptidase Activity Negative Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Protein Processing Positive Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Proteolysis Mitochondrial Membrane Organization Positive Regulation Of Organelle Organization Positive Regulation Of Protein Oligomerization Regulation Of Cellular Process Regulation Of Intracellular Transport Mitochondrion Organization
Tagcloud ?		abrogated abundance antiapoptotic barely bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing	aacr antiapoptotic antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized parental pharmacologic plk1 polo potently recur res rnai top volasertib xl
Tagcloud (Difference) ?		abrogated abundance barely bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf fgf10 fgf18 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing	aacr antiestrogens aromatase competitive deprivation drives escaped estrogen eventually fulvestrant hcc1428 junb kinome letrozole lted mcf7 ovariectomized parental pharmacologic plk1 polo potently recur res rnai top volasertib xl
Tagcloud (Intersection) ?		antiapoptotic