PLAAT4 and TGM1

Number of citations of the paper that reports this interaction (PubMedID 15846304)
0

Data Source:
HPRD (in vitro)

		PLAAT4	TGM1
Description		phospholipase A and acyltransferase 4	transglutaminase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Phospholipase A2 Activity Protein Binding Phospholipase A1 Activity N-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Negative Regulation Of Cell Population Proliferation Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling Positive Regulation Of Keratinocyte Differentiation N-acylphosphatidylethanolamine Metabolic Process Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development
Pathways		Acyl chain remodelling of PE	Formation of the cornified envelope
Drugs
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS
Interacting Genes		6 interacting genes: HRAS PIK3R3 SGTA TGM1 TRIM25 UBE2I	34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4
Entrez ID		5920	7051
HPRD ID		05479	01824
Ensembl ID		ENSG00000133321	ENSG00000092295
Uniprot IDs		Q9UL19	P22735
PDB IDs		2LKT 2MY9 7ZOT	2XZZ
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Regulation Of Fibroblast Proliferation Insulin Receptor Signaling Pathway Fibroblast Proliferation GTPase Complex Modulation Of Chemical Synaptic Transmission Cytosol Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity TRC Complex ERAD Pathway Cell Envelope Organization SUMO Conjugating Enzyme Activity Positive Regulation Of Cell Migration Phospholipase C Activator Activity Positive Regulation Of Cell Motility RING-like Zinc Finger Domain Binding RIG-I Binding Positive Regulation Of Locomotion T Cell Differentiation BAT3 Complex Binding SUMO Ligase Complex HLH Domain Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Synaptic Plasticity Positive Regulation Of Epithelial Cell Proliferation Oncogene-induced Cell Senescence Immune System Process Protein Modification Process T-helper 2 Cell Differentiation Unmethylated CpG Binding MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Transferase Activity Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Protein Metabolic Process Regulation Of Heterochromatin Formation Response To Endoplasmic Reticulum Stress Proteolysis Involved In Protein Catabolic Process Negative Regulation Of ERAD Pathway Protein-glutamine Gamma-glutamyltransferase Activity Small Protein Activating Enzyme Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction RIG-I Signaling Pathway 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA T-helper 1 Type Immune Response	Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity
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