ZBTB12

Description		zinc finger and BTB domain containing 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clostridioides difficle infection ( 33841421) Clostridioides difficle infection in antibiotics-users ( 33841421) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: GRB2 HRAS NCK2 RAP1GAP ZBTB26
Entrez ID		221527
HPRD ID		15691
Ensembl ID		ENSG00000204366
Uniprot IDs		Q9Y330
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Positive Regulation Of Protein Polymerization Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Guanyl-nucleotide Exchange Factor Adaptor Activity Endocytosis Regulation Of Actin Filament-based Process Schwann Cell Development ERBB Signaling Pathway Glial Cell Development Regulation Of Cell-cell Adhesion Cellular Response To Ionizing Radiation Positive Regulation Of Actin Filament Polymerization Insulin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Myelination Axon Ensheathment Vesicle Membrane Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Negative Regulation Of Microvillus Assembly Regulation Of Immune System Process Import Into Cell Regulation Of Actin Filament Polymerization Enzyme-linked Receptor Protein Signaling Pathway Grb2-EGFR Complex GTPase Complex Cellular Response To Glial Cell Derived Neurotrophic Factor Immune System Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Response To Ionizing Radiation Negative Regulation Of Cell Population Proliferation Antigen Receptor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Phospholipase C Activator Activity Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Adhesion Cellular Response To Radiation Positive Regulation Of Cytoskeleton Organization Response To Glial Cell Derived Neurotrophic Factor Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
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