ZBTB12 and RAP1GAP

Number of citations of the paper that reports this interaction (PMID 8939933)
11

Data Source:
HPRD (two hybrid, in vitro)

		ZBTB12	RAP1GAP
Gene Name		zinc finger and BTB domain containing 12	RAP1 GTPase activating protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Golgi Membrane Cytosol Membrane
	Molecular Function	DNA Binding Metal Ion Binding	GTPase Activity GTPase Activator Activity Protein Binding Ras GTPase Binding Protein Homodimerization Activity Rap GTPase Activator Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Signal Transduction Metabolic Process Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity Negative Regulation Of Microvillus Assembly
Pathways			Rap1 signalling Adaptive Immune System
Drugs
Diseases
GWAS		Hematology traits ( 23263863)	Liver enzyme levels ( 18940312)
Protein-Protein Interactions		2 interactors: HRAS RAP1GAP	15 interactors: BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B MLLT4 PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12
Entrez ID		221527	5909
HPRD ID		15691	02609
Ensembl ID		ENSG00000204366	ENSG00000076864
Uniprot IDs		Q9Y330	P47736
PDB IDs			1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Projection Assembly Negative Regulation Of Microvillus Assembly Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rac Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Microvillus Assembly Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Ruffle Assembly Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Regulation Of MiRNA Metabolic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Rap GTPase Activity Regulation Of Ruffle Assembly Negative Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Rap Protein Signal Transduction Cellular Senescence Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of GTPase Activity Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Regulation Of Actin Cytoskeleton Reorganization Social Behavior Positive Regulation Of Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Catalytic Activity Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Visual Behavior Activation Of MAPKK Activity Lung Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Replication Cell Aging Regulation Of Cellular Component Organization Associative Learning Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway See more	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Catalytic Activity Mitotic Nuclear Envelope Disassembly Regulation Of Synaptic Vesicle Transport Nuclear Envelope Disassembly Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Neurotransmitter Secretion Activation Of MAPKK Activity Nuclear Envelope Organization Positive Regulation Of Protein Modification Process Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Activation Of Protein Kinase Activity Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Rap GTPase Activity Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Positive Regulation Of Protein Metabolic Process Phosphorylation Regulation Of Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Regulation Of Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Rap Protein Signal Transduction Regulation Of Exocytosis Positive Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Endothelial Barrier Protein Localization To Chromosome Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Kinase Activity See more
Tagcloud ?			autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Difference) ?			autophosphorylated burst c3g crk detrimental fascin filamentous forced gradual gtpase guanine holds hyperactivation imperative irrespective labile microspikes motile n17rap1 presumed protrusions recruits releasing reverses sh3 unidentified v12rap1
Tagcloud (Intersection) ?