RANBP2 and SAE1

Number of citations of the paper that reports this interaction (PMID 11792325)
199

Data Source:
BioGRID (enzymatic study)

		RANBP2	SAE1
Gene Name		RAN binding protein 2	SUMO1 activating enzyme subunit 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Pore Mitochondrion Cytosol Membrane Nuclear Membrane Nuclear Inclusion Body Nuclear Pore Nuclear Basket	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Zinc Ion Binding Ran GTPase Binding Ligase Activity	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Protein Peptidyl-prolyl Isomerization Carbohydrate Metabolic Process Protein Folding Protein Import Into Nucleus Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Glucose Transport Viral Process Protein Sumoylation Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Negative Regulation Of Glucokinase Activity Small Molecule Metabolic Process MRNA Transport Transmembrane Transport Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown Mitotic Anaphase SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear Pore Complex (NPC) Disassembly Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Resolution of Sister Chromatid Cohesion Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport Mitotic Metaphase and Anaphase	Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		34 interactors: AKAP13 ARID4B CALM1 CDCA8 CUL1 FHOD1 HDAC4 IFT140 IPO5 KPNA1 KPNA2 KPNB1 LRPAP1 MDM2 NUP62 NXF1 OPN1LW OPN1MW PARK2 RAN RANGAP1 SAE1 SENP1 SP100 SUMO1 TAF1 TNPO1 TOP2B TP53 UBA2 UBE2I UBTD1 XPO1 XPOT	15 interactors: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 RANBP2 SP100 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39
Entrez ID		5903	10055
HPRD ID		03111	18010
Ensembl ID		ENSG00000153201	ENSG00000142230
Uniprot IDs		P49792	Q9UBE0
PDB IDs		1RRP 1XKE 1Z5S 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E 4LQW	1Y8Q 1Y8R 3KYC 3KYD
Enriched GO Terms of Interacting Partners?		Viral Process Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Localization To Organelle Cytoplasmic Transport Peptidyl-lysine Modification Protein Import Into Nucleus Nuclear Import Cellular Localization Protein Sumoylation Protein Import NLS-bearing Protein Import Into Nucleus Positive Regulation Of Metabolic Process Cellular Protein Localization Establishment Of Localization In Cell Intracellular Transport Mitotic Cell Cycle Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Protein Localization Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization To Organelle Nuclear Export Cellular Response To Organic Substance Regulation Of Protein Localization Regulation Of Protein Catabolic Process Cell Cycle Regulation Of Intracellular Protein Transport Protein Targeting Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Binding Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Establishment Of Protein Localization SMT3-dependent Protein Catabolic Process Intracellular Protein Transport Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Peptidyl-amino Acid Modification Positive Regulation Of Cellular Biosynthetic Process	Protein Sumoylation Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Peptidyl-amino Acid Modification Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inclusion Body Assembly Cellular Metabolic Process Protein Refolding Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Binding Response To Organic Substance Regulation Of Growth Regulation Of Binding Synaptonemal Complex Disassembly Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of SUMO Transferase Activity Protein Folding Response To Cytokine Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response SMT3-dependent Protein Catabolic Process
Tagcloud ?		adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 respective rps6kl1 sequenced sncaip spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Difference) ?		adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 respective rps6kl1 sequenced sncaip spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Intersection) ?