SAE1 and SP100

Number of citations of the paper that reports this interaction (PMID 11792325)
199

Data Source:
BioGRID (enzymatic study)

		SAE1	SP100
Gene Name		SUMO1 activating enzyme subunit 1	SP100 nuclear antigen
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol SUMO Activating Enzyme Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Mre11 Complex Nuclear Periphery
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Chromo Shadow Domain Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Sumoylation SMT3-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance Chromatin Remodeling Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Endothelial Cell Migration Viral Process Cytokine-mediated Signaling Pathway Response To Retinoic Acid Negative Regulation Of Viral Transcription Response To Cytokine Response To Type I Interferon Response To Interferon-gamma Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Export From Nucleus Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Component Movement Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		15 interactors: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 RANBP2 SP100 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39	38 interactors: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREM DNMT3A DYRK2 ETS1 GIPC2 HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML RANBP2 RBM39 RTP5 SAE1 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBA2 UBE2I USPL1 ZC2HC1A
Entrez ID		10055	6672
HPRD ID		18010	06844
Ensembl ID		ENSG00000142230	ENSG00000067066
Uniprot IDs		Q9UBE0	E7EUA7 P23497 Q6ZMK3
PDB IDs		1Y8Q 1Y8R 3KYC 3KYD	1H5P
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Peptidyl-lysine Modification Protein Modification By Small Protein Conjugation Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Peptidyl-amino Acid Modification Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inclusion Body Assembly Cellular Metabolic Process Protein Refolding Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Protein Localization To Nucleus Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Viral Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Binding Response To Organic Substance Regulation Of Growth Regulation Of Binding Synaptonemal Complex Disassembly Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of SUMO Transferase Activity Protein Folding Response To Cytokine Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Regulation Of Synapse Structure Or Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response SMT3-dependent Protein Catabolic Process	Protein Sumoylation PML Body Organization Regulation Of Metabolic Process Peptidyl-lysine Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Post-translational Protein Modification Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleus Organization Regulation Of Transcription, DNA-templated Peptidyl-amino Acid Modification Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Cellular Process SMT3-dependent Protein Catabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization Positive Regulation Of Proteolysis RNA-dependent DNA Replication Positive Regulation Of Cellular Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Chromosome Organization Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Protein Desumoylation Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Telomere Capping Chromatin Modification Positive Regulation Of Cellular Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase
Tagcloud ?			aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg
Tagcloud (Difference) ?			aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg
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