RAD51 and BCCIP

Number of citations of the paper that reports this interaction (PubMedID 15713648)
73

Data Source:
HPRD (in vivo)

		RAD51	BCCIP
Description		RAD51 recombinase	BRCA2 and CDKN1A interacting protein
Image
GO Annotations	Cellular Component	Nuclear Ubiquitin Ligase Complex Nuclear Chromosome Chromosome, Telomeric Region Chromatin Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Centrosome Cytosol Cytoskeleton PML Body Protein-containing Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm Presynaptic Intermediate Filament Cytoskeleton	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Spindle Pole
	Molecular Function	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity Enzyme Binding Identical Protein Binding DNA Polymerase Binding ATP-dependent DNA Damage Sensor Activity	RNA Binding Protein Binding Tubulin Binding Kinase Regulator Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Metabolic Process DNA Repair DNA Recombination Mitotic Recombination DNA Damage Response Meiosis I Reciprocal Meiotic Recombination Response To Xenobiotic Stimulus Response To Toxic Substance Response To X-ray Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Replication Fork Processing Telomere Organization Interstrand Cross-link Repair DNA Strand Invasion Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Cellular Response To Alkaloid Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Glucoside Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Recombination-dependent Replication Fork Processing Double-strand Break Repair Involved In Meiotic Recombination Regulation Of DNA Damage Checkpoint	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization DNA Repair DNA Damage Response Mitotic Spindle Organization Microtubule Anchoring Neuroendocrine Cell Differentiation Mitotic Spindle Assembly
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		99 interacting genes: ABL1 AGO2 ATM ATRX BARD1 BCCIP BCR BLM BRCA1 BRCA2 CASP3 CASP7 CASP8AP2 CCND1 CDH13 CHD3 CHEK1 CRYAA CSNK2A1 CSNK2B CST6 CTCF DDB2 DMC1 DNAJA3 ENAH EP400 ERCC2 ERCC5 EVL FANCD2 FANCI FBH1 FBXO5 FIRRM GMEB1 HID1 HNRNPC HSP90AA1 IL24 IRS1 ITIH5 MAPK8IP3 MCPH1 MDC1 MMS22L MSH4 NBN NCL NELFB NXF1 PARPBP PCSK1N PDS5B PFN1 PIAS1 PLK1 POLA1 RAD18 RAD51AP1 RAD51AP2 RAD51C RAD52 RAD54B RAD54L RAD54L2 RECQL5 RELA RFWD3 RNF20 RPA1 RPA2 RPA3 SEM1 SFR1 SIRT2 ST14 SUMO1 SUMO2 SWSAP1 TDG TFF1 TOPORS TP53 TP53BP1 UBE2I UCHL3 UGDH UHRF2 UMPS USP10 VASP VIM WDR48 WRN XPO1 XRCC2 XRCC3 ZDHHC17	28 interacting genes: ABCB1 BARD1 BRCA2 CAPZB CCDC33 CDC42 CDKN1A CPAP CSNK2B FCF1 GSK3A GSK3B H2BC15 HMGB2 ITSN2 MRPS9 OGT PDGFB PTN PTPRM RAD51 RALY RPL23 RPL38 SRC TENT5A ZNF138 ZNF19
Entrez ID		5888	56647
HPRD ID		01557	16542
Ensembl ID		ENSG00000051180	ENSG00000107949
Uniprot IDs		Q06609	Q9P287
PDB IDs		1B22 1N0W 5H1B 5H1C 5JZC 5NP7 5NWL 7C9A 7EJC 7EJE 8BQ2 8BR2 8BSC 8GYK 8JND 8JNE 8JNF 8PBC 8PBD 8R64 8RCD 8RCF 8XBT 8XBU 8XBV 8XBW 8XBX 8XBY	7KYQ 7KYS 8EQB 8EXE 8EXF
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Recombinational Repair Cellular Response To Stress DNA Recombination Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stress Macromolecule Metabolic Process Nucleus PML Body Signal Transduction In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Replication Fork Regulation Of Cell Cycle Single-stranded DNA Binding Response To Ionizing Radiation DNA Binding DNA Damage Checkpoint Signaling Response To Radiation Regulation Of DNA Repair Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Chromosome Organization Mitotic DNA Integrity Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Damaged DNA Binding Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Cell Cycle Process Site Of Double-strand Break Homologous Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Chromosome, Telomeric Region Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Negative Regulation Of DNA Recombination	Nuclear Ubiquitin Ligase Complex Mitotic Recombination-dependent Replication Fork Processing Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Damage Checkpoint Cellular Response To Ionizing Radiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Glycogen (starch) Synthase Activity Protein-containing Complex Regulation Of Epithelial Cell Proliferation Regulation Of Cell-substrate Adhesion Negative Regulation Of Catabolic Process Regulation Of Proteolysis Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell-substrate Adhesion Cellular Response To Interleukin-3 Response To Glycoside Regulation Of Protein Modification Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Response To Ionizing Radiation Regulation Of Protein Metabolic Process Response To Gamma Radiation Negative Regulation Of Proteolysis Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of TOR Signaling Cellular Response To Antibiotic Regulation Of Cell Migration Negative Regulation Of Catalytic Activity Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Regulation Of Intracellular Signal Transduction Cellular Response To Radiation Apoptotic Signaling Pathway Regulation Of Cell Motility
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