RAD51 and RAD51AP1

Number of citations of the paper that reports this interaction (PMID 9396801)
14

Data Source:
HPRD (in vitro, two hybrid)

		RAD51	RAD51AP1
Gene Name		RAD51 recombinase	RAD51 associated protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Microtubule Organizing Center PML Body Perinuclear Region Of Cytoplasm	Nucleus
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding Identical Protein Binding Single-stranded DNA-dependent ATPase Activity DNA Polymerase Binding	Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Unwinding Involved In DNA Replication DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination Cellular Response To DNA Damage Stimulus Meiotic Nuclear Division Reciprocal Meiotic Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Ligation Protein Homooligomerization Cellular Response To Ionizing Radiation Cellular Response To Camptothecin	Double-strand Break Repair Via Homologous Recombination DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Response To Ionizing Radiation
Pathways		Assembly of the RAD51-ssDNA nucleoprotein complex Homologous DNA pairing and strand exchange Meiotic recombination Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS			Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)
Protein-Protein Interactions		42 interactors: ABL1 ATM ATRX BCCIP BLM BRCA1 BRCA2 CASP3 CASP7 CHD3 CHEK1 DMC1 DNAJA3 ERCC2 FANCD2 FBXO18 HID1 HNRNPC IRS1 MDC1 NXF1 PFN1 RAD18 RAD51AP1 RAD51AP2 RAD51C RAD52 RAD54B RAD54L RPA1 RPA3 SFR1 SUMO1 SWI5 SWSAP1 TP53 UBE2I UGDH UHRF2 VIM WRN ZDHHC17	5 interactors: APP NEDD4 PALB2 RAD51 SIAH1
Entrez ID		5888	10635
HPRD ID		01557	04350
Ensembl ID		ENSG00000051180	ENSG00000111247
Uniprot IDs		Q06609	B4DUS5 Q96B01
PDB IDs		1B22 1N0W
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination Cellular Response To Stress Response To Stress Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Radiation Cellular Nitrogen Compound Metabolic Process Chromosome Organization Response To Ionizing Radiation Organelle Organization Cell Cycle Nitrogen Compound Metabolic Process Cellular Response To Stimulus DNA Duplex Unwinding DNA Geometric Change Response To Abiotic Stimulus Regulation Of Cell Cycle Response To Stimulus Cell Cycle Process DNA-dependent DNA Replication DNA Replication Signal Transduction In Response To DNA Damage Meiotic Nuclear Division Cellular Response To Ionizing Radiation DNA Conformation Change Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Aging Response To UV Meiotic Cell Cycle Cellular Response To Radiation DNA Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Cellular Metabolic Process Replication Fork Processing Cellular Response To Hydroxyurea Intrinsic Apoptotic Signaling Pathway Meiosis I Response To Gamma Radiation Signal Transduction By P53 Class Mediator DNA Recombinase Assembly Regulation Of Response To DNA Damage Stimulus	Neuromuscular Junction Development Neuron Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Response To Radiation Neuron Death Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Synapse Structure Or Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Response To Radiation Double-strand Break Repair Neuron Projection Development Synaptic Growth At Neuromuscular Junction Anatomical Structure Morphogenesis Synapse Organization Collateral Sprouting In Absence Of Injury Positive Regulation Of DNA Ligation Cellular Response To Camptothecin Neuron Development Intracellular Receptor Signaling Pathway Reproduction Response To Camptothecin Response To Abiotic Stimulus DNA Recombination Collateral Sprouting Axon Midline Choice Point Recognition DNA Recombinase Assembly Neuron Differentiation Cell Projection Organization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Progesterone Receptor Signaling Pathway Axon Choice Point Recognition Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Locomotion Developmental Growth Glucocorticoid Receptor Signaling Pathway Neuron Remodeling Response To Light Stimulus Response To Stress Cellular Response To Stress Protein Targeting To Lysosome Generation Of Neurons Axon Guidance Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway DNA Unwinding Involved In DNA Replication Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Lysosome
Tagcloud ?		boundary box cerevisiae consisting damaging declined delta dosage dsc1 elements enhances fluctuate fluctuation frequency mbf1 mbp1 mcb meiosis meiotic mitotic mlu rad54 recombination saccharomyces spore sporulation swi6 transcript viability	atm atr brca1 coactivator collectively depleted directed encode endocrine familial homologous joining lineage lost melanocytes melanoma melanomas men1 methyltransferase neoplasia nonhomologous oncogene promoters raising recombination stimulating suppressor trimethylation
Tagcloud (Difference) ?		boundary box cerevisiae consisting damaging declined delta dosage dsc1 elements enhances fluctuate fluctuation frequency mbf1 mbp1 mcb meiosis meiotic mitotic mlu rad54 saccharomyces spore sporulation swi6 transcript viability	atm atr brca1 coactivator collectively depleted directed encode endocrine familial homologous joining lineage lost melanocytes melanoma melanomas men1 methyltransferase neoplasia nonhomologous oncogene promoters raising stimulating suppressor trimethylation
Tagcloud (Intersection) ?		recombination