RAD51 and EVL

Number of citations of the paper that reports this interaction (PubMedID 19725871)
0

Data Source:
BioGRID (pull down, pull down)

		RAD51	EVL
Description		RAD51 recombinase	Enah/Vasp-like
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Ubiquitin Ligase Complex Nuclear Chromosome Chromosome, Telomeric Region Chromatin Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Centrosome Cytosol Cytoskeleton PML Body Protein-containing Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm Presynaptic Intermediate Filament Cytoskeleton	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Cell Projection
	Molecular Function	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity Enzyme Binding Identical Protein Binding DNA Polymerase Binding ATP-dependent DNA Damage Sensor Activity	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Metabolic Process DNA Repair DNA Recombination Mitotic Recombination DNA Damage Response Meiosis I Reciprocal Meiotic Recombination Response To Xenobiotic Stimulus Response To Toxic Substance Response To X-ray Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Replication Fork Processing Telomere Organization Interstrand Cross-link Repair DNA Strand Invasion Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Cellular Response To Alkaloid Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Glucoside Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Recombination-dependent Replication Fork Processing Double-strand Break Repair Involved In Meiotic Recombination Regulation Of DNA Damage Checkpoint	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Protein Homotetramerization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Supramolecular Fiber Organization
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)	Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		99 interacting genes: ABL1 AGO2 ATM ATRX BARD1 BCCIP BCR BLM BRCA1 BRCA2 CASP3 CASP7 CASP8AP2 CCND1 CDH13 CHD3 CHEK1 CRYAA CSNK2A1 CSNK2B CST6 CTCF DDB2 DMC1 DNAJA3 ENAH EP400 ERCC2 ERCC5 EVL FANCD2 FANCI FBH1 FBXO5 FIRRM GMEB1 HID1 HNRNPC HSP90AA1 IL24 IRS1 ITIH5 MAPK8IP3 MCPH1 MDC1 MMS22L MSH4 NBN NCL NELFB NXF1 PARPBP PCSK1N PDS5B PFN1 PIAS1 PLK1 POLA1 RAD18 RAD51AP1 RAD51AP2 RAD51C RAD52 RAD54B RAD54L RAD54L2 RECQL5 RELA RFWD3 RNF20 RPA1 RPA2 RPA3 SEM1 SFR1 SIRT2 ST14 SUMO1 SUMO2 SWSAP1 TDG TFF1 TOPORS TP53 TP53BP1 UBE2I UCHL3 UGDH UHRF2 UMPS USP10 VASP VIM WDR48 WRN XPO1 XRCC2 XRCC3 ZDHHC17	36 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CEBPA CFTR CRKL DNMBP ENAH FXR1 FXR2 FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		5888	51466
HPRD ID		01557	10942
Ensembl ID		ENSG00000051180	ENSG00000196405
Uniprot IDs		Q06609	A0A024R6K5 A0A2D1PGY7 Q9UI08
PDB IDs		1B22 1N0W 5H1B 5H1C 5JZC 5NP7 5NWL 7C9A 7EJC 7EJE 8BQ2 8BR2 8BSC 8GYK 8JND 8JNE 8JNF 8PBC 8PBD 8R64 8RCD 8RCF 8XBT 8XBU 8XBV 8XBW 8XBX 8XBY
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Recombinational Repair Cellular Response To Stress DNA Recombination Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stress Macromolecule Metabolic Process Nucleus PML Body Signal Transduction In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Replication Fork Regulation Of Cell Cycle Single-stranded DNA Binding Response To Ionizing Radiation DNA Binding DNA Damage Checkpoint Signaling Response To Radiation Regulation Of DNA Repair Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Chromosome Organization Mitotic DNA Integrity Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Damaged DNA Binding Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Cell Cycle Process Site Of Double-strand Break Homologous Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Chromosome, Telomeric Region Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Negative Regulation Of DNA Recombination	Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Actin Filament-based Process Cytoskeleton Actin Filament Organization Fc-gamma Receptor Signaling Pathway Actin Cytoskeleton Organization Supramolecular Fiber Organization Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Migration Cell Motility Actin Polymerization Or Depolymerization Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Ephrin Receptor Binding Regulation Of Cell Projection Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Component Organization Regulation Of Cell Shape Negative Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Response To Xenobiotic Stimulus Cell Junction Anatomical Structure Morphogenesis Cell Projection Organization Cytoplasm Cellular Response To Transforming Growth Factor Beta Stimulus Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein Tyrosine Kinase Activity Regulation Of Developmental Process Synapse Protein-containing Complex Regulation Of Actin Cytoskeleton Organization Leukocyte Migration Regulation Of Cell Projection Assembly Immune Response-activating Signaling Pathway
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