RHNO1 and RAD1

Number of citations of the paper that reports this interaction (PubMedID 31776186)
25

Data Source:
BioGRID (pull down)

		RHNO1	RAD1
Description		RAD9-HUS1-RAD1 interacting nuclear orphan 1	RAD1 checkpoint DNA exonuclease
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Site Of Double-strand Break	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex
	Molecular Function	Protein Binding Chromatin-protein Adaptor Activity	Damaged DNA Binding Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity
	Biological Process	DNA Damage Checkpoint Signaling Recombinational Repair DNA Repair Chromatin Organization DNA Damage Response Cellular Response To UV Positive Regulation Of G0 To G1 Transition Cellular Response To Ionizing Radiation Double-strand Break Repair Via Alternative Nonhomologous End Joining Protein Localization To Site Of Double-strand Break	DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Substantia Nigra Development Meiotic Recombination Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Daytime sleep phenotypes ( 27126917)
Interacting Genes		11 interacting genes: BANP CYSRT1 GOLGA2 HUS1 KRTAP10-3 KRTAP10-8 KRTAP10-9 LZTS2 RAD1 RAD9A TFIP11	24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN
Entrez ID		83695	5810
HPRD ID		17487	04400
Ensembl ID		ENSG00000171792	ENSG00000113456
Uniprot IDs		Q9BSD3	O60671
PDB IDs		6J8Y 8WU8	3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex Double-stranded DNA 3'-5' DNA Exonuclease Activity Cellular Response To Ionizing Radiation Meiotic Cell Cycle Checkpoint Signaling Keratin Filament DNA Damage Checkpoint Signaling Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Intermediate Filament Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Primary Ureteric Bud Growth Mitotic DNA Integrity Checkpoint Signaling DNA Metabolic Process Mitotic DNA Damage Checkpoint Signaling DNA Damage Response Negative Regulation Of Cell Cycle Meiotic DNA Integrity Checkpoint Signaling Spliceosomal Complex Disassembly Telomere Maintenance Meiotic Recombination Checkpoint Signaling U2-type Post-mRNA Release Spliceosomal Complex Response To Radiation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Glycosylation Telomere Organization DNA Repair Golgi Disassembly Regulation Of Protein Glycosylation Protection From Non-homologous End Joining At Telomere Ureter Morphogenesis Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Importin-alpha Family Protein Binding Negative Regulation Of Meiotic Nuclear Division Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Microtubule Severing Golgi Ribbon Formation Mitotic DNA Replication Checkpoint Signaling Golgi Cis Cisterna Negative Regulation Of Mitotic Cell Cycle Spindle Midzone Assembly	DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Stress Base-excision Repair Double-strand Break Repair Damaged DNA Binding DNA Recombination Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Response To Stress Recombinational Repair Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage Site Of Double-strand Break Protein Localization To Site Of Double-strand Break Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Response To Radiation Mitotic DNA Integrity Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Cycle Phase Transition Chromosome Organization Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleoplasm DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Process Oxidized Purine DNA Binding Protein Localization To Chromosome Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Replication Checkpoint Signaling Response To Ionizing Radiation Mismatched DNA Binding Regulation Of Cell Cycle Process Response To UV Single Guanine Insertion Binding Chromosome, Telomeric Region Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Telomere Maintenance Chromatin-protein Adaptor Activity Guanine/thymine Mispair Binding Nucleotide-excision Repair Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Telomere Organization Checkpoint Clamp Complex Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination
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