B4GALT7 and RABGGTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		B4GALT7	RABGGTB
Description		beta-1,4-galactosyltransferase 7	Rab geranylgeranyltransferase subunit beta
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Golgi Cisterna Membrane	Cytoplasm Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Protein Binding Galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Xylosylprotein 4-beta-galactosyltransferase Activity Metal Ion Binding	Catalytic Activity Prenyltransferase Activity Protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Protein Modification Process Negative Regulation Of Fibroblast Proliferation Glycosylation Supramolecular Fiber Organization	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Visual Perception Protein Geranylgeranylation Protein Modification Process
Pathways		Glycosaminoglycan-protein linkage region biosynthesis Defective B4GALT7 causes EDS, progeroid type	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation
Drugs			N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases		Ehlers-Danlos syndrome, progeroid form Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Blood protein levels ( 30072576) Methadone dose in opioid dependence ( 28115739) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)
Interacting Genes		7 interacting genes: CYSRT1 KRT31 KRTAP10-3 KRTAP10-7 RABGGTB TMEM14B UBC	19 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A SH3GLB1 TAFA1 TMEM25 WDR4
Entrez ID		11285	5876
HPRD ID		05060	01532
Ensembl ID		ENSG00000027847	ENSG00000137955
Uniprot IDs		B3KMT1 Q9UBV7	A8KAJ2 P53611 Q6IB63
PDB IDs		4IRP 4IRQ	6J6X 6J74 6J7F 6J7X 6O60
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament	G Protein Activity GTPase Activity Myosin V Binding GTP Binding Endosome Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Synaptic Vesicle Recycling Protein Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Exocytosis Positive Regulation Of Exocytosis Pigment Granule Localization Establishment Of Protein Localization Nucleotide Binding Exosomal Secretion Intracellular Protein Localization Organelle Localization Synaptic Vesicle Membrane Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Amyloid-beta Clearance By Transcytosis Cytoplasmic Vesicle Hydrolase Activity Presynaptic Endosome Regulation Of Neuronal Synaptic Plasticity Regulation Of Secretion Plasma Membrane To Endosome Transport Golgi Apparatus GDP Binding Endosome To Plasma Membrane Protein Transport Phagocytic Vesicle Neurotransmitter Receptor Transport Regulation Of Plasma Membrane Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Secretory Granule Membrane Endosomal Transport Melanosome Transcytosis Melanosome Membrane Positive Regulation Of Secretion By Cell Early Endosome To Late Endosome Transport Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway
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