PYGM and S100A1

Number of citations of the paper that reports this interaction (PMID 12804600)
12

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		PYGM	S100A1
Gene Name		phosphorylase, glycogen, muscle	S100 calcium binding protein A1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleus Sarcoplasmic Reticulum Z Disc M Band Neuron Projection Protein Complex
	Molecular Function	Nucleotide Binding Glycogen Phosphorylase Activity Pyridoxal Phosphate Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Glucose Metabolic Process Pathogenesis Small Molecule Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Glucose metabolism Glycogen breakdown (glycogenolysis) Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs		Pyridoxal Phosphate Beta-D-Glucopyranose Spirohydantoin 3-Amino-8,9,10-Trihydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione Alpha-D-Glucose-6-Phosphate 1-N-Acetyl-Beta-D-Glucosamine Fluoro-Phosphite Ion Beta-D-Glucose 3,8,9,10-Tetrahydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione Nojirimycine Tetrazole Indirubin-5-Sulphonate 2-Deoxy-Glucose-6-Phosphate C-(1-Hydrogyl-Beta-D-Glucopyranosyl) Formamide Alpha-D-Glucopyranosyl-2-Carboxylic Acid Amide Alpha-D-Glucose-1-Phosphate 8,9,10-Trihydroxy-7-Hydroxymethyl-2-Thioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Decan-4-One 4-{2,4-Bis[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole N-Acetyl-N\'-Beta-D-Glucopyranosyl Urea 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Benzothiazole C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Oxadiazole 5-Chloro-1h-Indole-2-Carboxylic Acid [1-(4-Fluorobenzyl)-2-(4-Hydroxypiperidin-1yl)-2-Oxoethyl]Amide (3,4,5-Trihydroxy-6-Hydroxymethyl-Tetrahydro-Pyran-2-Yl)-Phosphoramidic Acid Dimethyl Ester 8,9,10-Trihydroxy-7-Hydroxymethyl-3-Methyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione Flavopiridol 1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose N-(8,9,10-Trihydroxy-7-Hydroxymethyl-2,4-Dioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Dec-3-Yl-Acetamide 1-Deoxy-1-Methoxycarbamido-Beta-D-Gluco-2-Heptulopyranosonamide 4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid 2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium N\'-Pyridoxyl-Lysine-5\'-Monophosphate Heptulose-2-Phosphate N-Benzoyl-N\'-Beta-D-Glucopyranosyl Urea Phosphonoserine 1-Deoxy-1-Acetylamino-Beta-D-Gluco-2-Heptulopyranosonamide Inosinic Acid 7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID 4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID 4-{4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2,3-DIMETHYL-PHENOXY}-BUTYRIC ACID 5-{3-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2-METHYL-PHENOXY}-PENTANOIC ACID 2-CHLORO-N-[(1R,2R)-1-HYDROXY-2,3-DIHYDRO-1H-INDEN-2-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE 2-CHLORO-N-[(3R)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL ({[(3E)-2\'-OXO-2\',7\'-DIHYDRO-2,3\'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID (5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-phenyl-1,6-dioxa-2-azaspiro[4.5]dec-2-ene-8,9,10-triol 2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methylphenyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol	Olopatadine
Diseases
GWAS		Urate levels ( 21768215)
Protein-Protein Interactions		6 interactors: PPP2R5A PRKAB2 S100A1 TOP1 TRIM63 WDYHV1	24 interactors: ACTA1 AGER ANXA6 ATP2A2 CACYBP CAPZA1 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM RYR1 S100A2 S100A4 S100B S100P SYN1
Entrez ID		5837	6271
HPRD ID		01986	01489
Ensembl ID		ENSG00000068976	ENSG00000160678
Uniprot IDs		P11217	P23297
PDB IDs		1Z8D	2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX
Enriched GO Terms of Interacting Partners?			Muscle System Process Response To Abiotic Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Protein Complex Assembly Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Muscle Contraction Relaxation Of Cardiac Muscle Regulation Of Striated Muscle Contraction Glycogen Catabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Polysaccharide Catabolic Process Calcium Ion Transport Relaxation Of Muscle Striated Muscle Tissue Development Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Response To Hormone Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Metal Ion Muscle Tissue Development Cellular Component Assembly Myotube Cell Development Regulation Of Cellular Localization Cellular Carbohydrate Catabolic Process Regulation Of The Force Of Heart Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Response To Wounding Regulation Of Ion Homeostasis Regulation Of Actin Filament-based Process Cellular Metal Ion Homeostasis Cellular Response To Alkaloid Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Astrocyte Differentiation Cytosolic Calcium Ion Homeostasis Cellular Cation Homeostasis Actin-mediated Cell Contraction Cellular Ion Homeostasis Response To Peptide Hormone Cardiac Conduction Tissue Development Negative Regulation Of Striated Muscle Tissue Development Steroid Hormone Receptor Complex Assembly Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Schwann Cell Proliferation
Tagcloud ?		add assignments calm1 confirmation cryab ests fourteen heterologous homologues localizations locations mapping myh7 myl1 painting panels pdk4 pgam2 pig porcine rev3l rfc1 sln sptbn1 srm160 tags tpm1 untranslated ywhag	ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Difference) ?		add assignments calm1 confirmation cryab ests fourteen heterologous homologues localizations locations mapping myh7 myl1 painting panels pdk4 pgam2 pig porcine rev3l rfc1 sln sptbn1 srm160 tags tpm1 untranslated ywhag	ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Intersection) ?