PYGM and NIPSNAP2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		PYGM	NIPSNAP2
Description		glycogen phosphorylase, muscle associated	nipsnap homolog 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Glycogen Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pyridoxal Phosphate Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process	Mitophagy Autophagy Mitochondrion Organization Positive Regulation Of High Voltage-gated Calcium Channel Activity
Pathways		Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)	RHOH GTPase cycle RHOJ GTPase cycle
Drugs		Pyridoxal phosphate Beta-D-Glucopyranose Spirohydantoin (5S,7R,8S,9S,10R)-3-Amino-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione alpha-D-glucose 6-phosphate N-beta-D-glucopyranosylacetamide Monofluorophosphate ion Beta-D-Glucose 3,8,9,10-tetrahydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione Nojirimycine Tetrazole Indirubin-5-sulphonate 2-Deoxy-Glucose-6-Phosphate C-(1-hydrogyl-beta-D-glucopyranosyl) formamide alpha-D-glucopyranosyl-2-carboxylic acid amide alpha-D-glucose-1-phosphate 8,9,10-Trihydroxy-7-hydroxymethyl-2-thioxo-6-oxa-1,3-diaza-spiro[4.5]decan-4-one 4-{2,4-Bis[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole N-acetyl-N'-beta-D-glucopyranosyl urea 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Benzothiazole C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Oxadiazole CP-320626 (3,4,5-Trihydroxy-6-Hydroxymethyl-Tetrahydro-Pyran-2-Yl)-Phosphoramidic Acid Dimethyl Ester 8,9,10-trihydroxy-7-hydroxymethyl-3-methyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione Alvocidib 1-deoxy-1-methoxycarbamido-beta-D-glucopyranose N-[(5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-(hydroxymethyl)-2,4-dioxo-6-oxa-1,3-diazaspiro[4.5]dec-3-yl]acetamide 1-Deoxy-1-methoxycarbamido-beta-D-gluco-2-heptulopyranosonamide 4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid 2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium N(6)-(pyridoxal phosphate)-L-lysine Heptulose-2-Phosphate N-(Benzoylcarbamoyl)-beta-D-glucopyranosylamine Dexfosfoserine 1-Deoxy-1-acetylamino-beta-D-gluco-2-heptulopyranosonamide Inosinic Acid 7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID 4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID 4-{4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2,3-DIMETHYL-PHENOXY}-BUTYRIC ACID 5-{3-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2-METHYL-PHENOXY}-PENTANOIC ACID 2-CHLORO-N-[(1R,2R)-1-HYDROXY-2,3-DIHYDRO-1H-INDEN-2-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE 2-CHLORO-N-[(3R)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL ({[(3E)-2'-Oxo-2',7'-dihydro-2,3'-biindol-3(7H)-ylidene]amino}oxy)acetic acid (5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-phenyl-1,6-dioxa-2-azaspiro[4.5]dec-2-ene-8,9,10-triol 2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methylphenyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Urate levels ( 21768215)	Alanine aminotransferase levels ( 33339817) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		28 interacting genes: AGTPBP1 ARID1B CDC42BPB CLASP2 DNM2 FAM110A IGBP1 INTS4 LMNA NIPSNAP2 NTAQ1 PDE4DIP POMP PPP1CA PPP1R3B PPP2CA PRKAB2 PYGL S100A1 SGCG SRP72 TOP1 TRAPPC2 TRIM54 TRIM55 TRIM63 TTN WWP1	3 interacting genes: PRNP PYGM UBC
Entrez ID		5837	2631
HPRD ID		01986	04302
Ensembl ID		ENSG00000068976	ENSG00000146729
Uniprot IDs		P11217	O75323
PDB IDs		1Z8D
Enriched GO Terms of Interacting Partners?		RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cortical Microtubule Plus-end Regulation Of Carbohydrate Catabolic Process M Band Cytoplasm Regulation Of Microtubule Polymerization Or Depolymerization Glycogen Granule Regulation Of Microtubule-based Process Regulation Of Glycogen Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Z Disc Glycogen Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Microtubule Energy Reserve Metabolic Process Protein Phosphatase Type 1 Complex Polysaccharide Metabolic Process Cytosol Microtubule-based Process Positive Regulation Of Glycogen Biosynthetic Process INTAC Complex Microtubule Organizing Center Organization Response To Lead Ion Negative Regulation Of Glycolytic Process RNA Polymerase II Transcription Initiation Surveillance Organelle Organization Protein Phosphatase 1 Binding Negative Regulation Of ATP Metabolic Process I Band Actomyosin Structure Organization Establishment Of Organelle Localization Regulation Of Glycogen Biosynthetic Process Cytoskeleton Organization Protein Modification Process Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Microtubule Depolymerization RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Phosphoprotein Phosphatase Activity Nuclear RNA Surveillance Regulation Of Microtubule Depolymerization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Membrane Tubulation Centrosome Cycle Vesicle Scission Cytoskeleton Positive Regulation Of High Voltage-gated Calcium Channel Activity Protein Phosphatase Regulator Activity	ATP-dependent Protein Binding Negative Regulation Of Calcineurin-NFAT Signaling Cascade Mitochondrial Outer Membrane Positive Regulation Of Glutamate Receptor Signaling Pathway Inclusion Body Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Interleukin-17 Production Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Glycosaminoglycan Binding Extrinsic Component Of Membrane Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Targeting To Membrane Extracellular Exosome Dendritic Spine Maintenance Type 8 Metabotropic Glutamate Receptor Binding Negative Regulation Of Amyloid-beta Formation Molecular Function Activator Activity Cuprous Ion Binding Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Copper Ion Homeostasis Negative Regulation Of Interleukin-2 Production Cellular Response To Copper Ion Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Polysaccharide Catabolic Process 1,4-alpha-oligoglucan Phosphorylase Activity Glycogen Catabolic Process Glycogen Phosphorylase Activity Protein Tag Activity Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Protein Targeting To Membrane Dendritic Spine Organization Negative Regulation Of T Cell Receptor Signaling Pathway Response To Copper Ion Long-term Memory Regulation Of Activated T Cell Proliferation Regulation Of Long-term Synaptic Potentiation Neuron Projection Organization Regulation Of Amyloid-beta Formation Terminal Bouton Negative Regulation Of Type II Interferon Production
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