PYGB and PYGL

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PYGB	PYGL
Description		glycogen phosphorylase B	glycogen phosphorylase L
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Glycogen Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pyridoxal Phosphate Binding	Nucleotide Binding Purine Nucleobase Binding Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding ATP Binding D-glucose Binding Glycogen Phosphorylase Activity AMP Binding Transferase Activity Glycosyltransferase Activity Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Identical Protein Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Response To Bacterium Glucose Homeostasis Necroptotic Process
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Pyridoxal phosphate Alvocidib
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Brain morphology (MOSTest) ( 32665545) Calcium levels ( 24068962) Diisocyanate-induced asthma ( 25918132) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Platelet distribution width ( 32888494) Serum alkaline phosphatase levels ( 31666285) Telomere length ( 30185882) TPE interval (resting) ( 32386560)	Acute lymphoblastic leukemia (childhood) ( 23007406) Blood protein levels ( 30072576) Psychosis (atypical) ( 24132900) Rectal cancer ( 33632709)
Interacting Genes		4 interacting genes: ACTN1 PPP1R3B PYGL SIAH1	7 interacting genes: BAG1 CEBPA HSD17B10 HSD3B7 IDH2 PYGB PYGM
Entrez ID		5834	5836
HPRD ID		00720	01987
Ensembl ID		ENSG00000100994	ENSG00000100504
Uniprot IDs		P11216	P06737
PDB IDs		5IKO 5IKP	1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW 8EMS
Enriched GO Terms of Interacting Partners?		Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Structural Constituent Of Postsynapse Vitamin Binding Purine Nucleobase Binding Transcription Termination Site Sequence-specific DNA Binding Negative Regulation Of Glycogen Catabolic Process [phosphorylase] Phosphatase Activity Transmembrane Transporter Binding Platelet Morphogenesis Glycogen Phosphorylase Activity Cell-cell Junction Cell Junction Cell Morphogenesis Identical Protein Binding Actin Filament Network Formation Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction 1,4-alpha-oligoglucan Phosphorylase Activity Energy Derivation By Oxidation Of Organic Compounds 5'-3' RNA Exonuclease Activity Glycogen Granule Blood Vessel Maturation Fibrinogen Binding Bile Acid Binding Termination Of RNA Polymerase II Transcription Fascia Adherens Regulation Of Glycogen Catabolic Process Vascular Endothelial Growth Factor Receptor 2 Binding Glycogen Binding Cell Junction Assembly D-glucose Binding 5'-3' Exonuclease Activity Vinculin Binding BMP Receptor Binding Macromolecule Catabolic Process AMP Binding Beta-catenin Destruction Complex Endothelial Cell Morphogenesis Negative Regulation Of Microtubule Polymerization Generation Of Precursor Metabolites And Energy Protein Phosphatase Type 1 Complex Necroptotic Process	Glycogen Phosphorylase Activity 1,4-alpha-oligoglucan Phosphorylase Activity Bile Acid Biosynthetic Process Polysaccharide Catabolic Process Glycogen Catabolic Process Bile Acid Metabolic Process Steroid Metabolic Process Generation Of Precursor Metabolites And Energy RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Pyridoxal Phosphate Binding Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity Carbohydrate Metabolic Process Response To Vitamin B2 C/EBP Complex 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Glyoxylate Cycle Isocitrate Dehydrogenase (NADP+) Activity Monocarboxylic Acid Metabolic Process CHOP-C/EBP Complex Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Carbohydrate Catabolic Process 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Oxidoreductase Activity White Fat Cell Proliferation Mitochondrial RNA 5'-end Processing Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Isoleucine Metabolic Process L-isoleucine Catabolic Process Isocitrate Metabolic Process Epsilon DNA Polymerase Complex B Cell Chemotaxis Small Molecule Metabolic Process TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
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