PYGB

Description		glycogen phosphorylase B
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Glycogen Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Pyridoxal phosphate Alvocidib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Calcium levels ( 24068962) Diisocyanate-induced asthma ( 25918132) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Platelet distribution width ( 32888494) Serum alkaline phosphatase levels ( 31666285) Telomere length ( 30185882) TPE interval (resting) ( 32386560)
Novel Interacting Genes		2 novel interacting genes: CDH5 XRN2
Interacting Genes		4 interacting genes: ACTN1 PPP1R3B PYGL SIAH1
Entrez ID		5834
HPRD ID		00720
Ensembl ID		ENSG00000100994
Uniprot IDs		P11216
PDB IDs		5IKO 5IKP
Enriched GO Terms of Interacting Partners?		Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Structural Constituent Of Postsynapse Vitamin Binding Purine Nucleobase Binding Transcription Termination Site Sequence-specific DNA Binding Negative Regulation Of Glycogen Catabolic Process [phosphorylase] Phosphatase Activity Transmembrane Transporter Binding Platelet Morphogenesis Glycogen Phosphorylase Activity Cell-cell Junction Cell Junction Cell Morphogenesis Identical Protein Binding Actin Filament Network Formation Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction 1,4-alpha-oligoglucan Phosphorylase Activity Energy Derivation By Oxidation Of Organic Compounds 5'-3' RNA Exonuclease Activity Glycogen Granule Blood Vessel Maturation Fibrinogen Binding Bile Acid Binding Termination Of RNA Polymerase II Transcription Fascia Adherens Regulation Of Glycogen Catabolic Process Vascular Endothelial Growth Factor Receptor 2 Binding Glycogen Binding Cell Junction Assembly D-glucose Binding 5'-3' Exonuclease Activity Vinculin Binding BMP Receptor Binding Macromolecule Catabolic Process AMP Binding Beta-catenin Destruction Complex Endothelial Cell Morphogenesis Negative Regulation Of Microtubule Polymerization Generation Of Precursor Metabolites And Energy Protein Phosphatase Type 1 Complex Necroptotic Process
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