PYGB and PPP1R3B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PYGB	PPP1R3B
Description		glycogen phosphorylase B	protein phosphatase 1 regulatory subunit 3B
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane Azurophil Granule Lumen Extracellular Exosome	Protein Phosphatase Type 1 Complex Glycogen Granule
	Molecular Function	Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Glycogen Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pyridoxal Phosphate Binding	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Enzyme Binding [phosphorylase] Phosphatase Activity Glycogen Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glycogen Catabolic Process
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Pyridoxal phosphate Alvocidib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Calcium levels ( 24068962) Diisocyanate-induced asthma ( 25918132) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Platelet distribution width ( 32888494) Serum alkaline phosphatase levels ( 31666285) Telomere length ( 30185882) TPE interval (resting) ( 32386560)	Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Alcohol use disorder (consumption score) ( 30940813) Aluminium levels ( 26025379) Alzheimer's disease ( 22832961) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee or tea ( 33287642) Cholesterol, total ( 25961943 20686565 24097068) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) FEV1 ( 30804560) Fibrinogen levels ( 28107422) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pregnancy) ( 23903356) Glycine levels ( 31070104) HDL cholesterol ( 20686565 21347282 23505323 23726366 25961943 24097068) HDL cholesterol levels ( 28334899) Joint mobility (Beighton score) ( 27182965) LDL cholesterol ( 20686565 20864672 25961943 24097068) LDL cholesterol levels ( 28334899) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alkaline phosphatase) ( 22001757) Liver volume ( 34128465) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483 22916037) Myopia (pathological) ( 23049088) Neuroticism ( 29255261) Nose size ( 27182965) Number of sexual partners ( 30643258) Peak expiratory flow ( 30804560) Plasma lactate levels ( 26433129) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: ACTN1 PPP1R3B PYGL SIAH1	7 interacting genes: IFNAR2 PLCE1 PPP1CA PPP1CB PRKAB2 PYGB PYGM
Entrez ID		5834	79660
HPRD ID		00720	17894
Ensembl ID		ENSG00000100994	ENSG00000173281
Uniprot IDs		P11216	Q86XI6
PDB IDs		5IKO 5IKP	2EEF 5ZT0
Enriched GO Terms of Interacting Partners?		Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Structural Constituent Of Postsynapse Vitamin Binding Purine Nucleobase Binding Transcription Termination Site Sequence-specific DNA Binding Negative Regulation Of Glycogen Catabolic Process [phosphorylase] Phosphatase Activity Transmembrane Transporter Binding Platelet Morphogenesis Glycogen Phosphorylase Activity Cell-cell Junction Cell Junction Cell Morphogenesis Identical Protein Binding Actin Filament Network Formation Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction 1,4-alpha-oligoglucan Phosphorylase Activity Energy Derivation By Oxidation Of Organic Compounds 5'-3' RNA Exonuclease Activity Glycogen Granule Blood Vessel Maturation Fibrinogen Binding Bile Acid Binding Termination Of RNA Polymerase II Transcription Fascia Adherens Regulation Of Glycogen Catabolic Process Vascular Endothelial Growth Factor Receptor 2 Binding Glycogen Binding Cell Junction Assembly D-glucose Binding 5'-3' Exonuclease Activity Vinculin Binding BMP Receptor Binding Macromolecule Catabolic Process AMP Binding Beta-catenin Destruction Complex Endothelial Cell Morphogenesis Negative Regulation Of Microtubule Polymerization Generation Of Precursor Metabolites And Energy Protein Phosphatase Type 1 Complex Necroptotic Process	Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glycogen Phosphorylase Activity 1,4-alpha-oligoglucan Phosphorylase Activity PTW/PP1 Phosphatase Complex Generation Of Precursor Metabolites And Energy Carbohydrate Metabolic Process Glycogen Catabolic Process Entrainment Of Circadian Clock By Photoperiod Polysaccharide Catabolic Process Photoperiodism Entrainment Of Circadian Clock Pyridoxal Phosphate Binding Circadian Regulation Of Gene Expression Phosphatase Activity Myosin-light-chain-phosphatase Activity Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Kinase Binding Type I Interferon Receptor Activity Type I Interferon Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Circadian Rhythm Carbohydrate Catabolic Process JAK Pathway Signal Transduction Adaptor Activity Dephosphorylation Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Phosphoprotein Phosphatase Activity Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Myosin Phosphatase Activity Diacylglycerol Biosynthetic Process Chromosome, Telomeric Region Glycogen Granule AMP-activated Protein Kinase Activity Glycosyltransferase Activity RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Double-strand Break Repair Via Alternative Nonhomologous End Joining Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Rhythmic Process Nucleotide-activated Protein Kinase Complex Extracellular Exosome Phospholipase C Activity Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex
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