RPL14 and PHLDA1

Number of citations of the paper that reports this interaction (PubMedID 11369516)
0

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro, in vivo)

		RPL14	PHLDA1
Description		ribosomal protein L14	pleckstrin homology like domain family A member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Postsynaptic Density Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding	Protein Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Cytoplasmic Translation RRNA Processing Translation Ribosomal Large Subunit Biogenesis	Apoptotic Process Positive Regulation Of Apoptotic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Interaction between PHLDA1 and AURKA MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Artenimol
Diseases
GWAS		Neuroticism ( 29255261)	Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Atrial fibrillation ( 29892015 30061737) Blood trace element (Cu levels) ( 23720494) Blood urea nitrogen levels ( 29403010 31152163) Creatinine levels ( 29403010) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		8 interacting genes: ALG13 FBXO7 KCNK4 KLF10 PEX5 PHLDA1 PTEN TLE6	43 interacting genes: APP CDPF1 CREBBP CYSRT1 EIF3D F2RL1 FBXO7 HSPA4 HSPA4L KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP5-1 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LGALS13 MDFI NBPF19 NOTCH2NLA PABPC4 PLSCR1 RPL14 TRAF4 TRAF6 TRIM42 TSPAN4
Entrez ID		9045	22822
HPRD ID		10617	05625
Ensembl ID		ENSG00000188846	ENSG00000139289
Uniprot IDs		P50914	Q8WV24
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Lewy Body Core Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Temperature-gated Cation Channel Activity Response To Arachidonate Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Arachidonate Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Response To Ultrasound Response To Alkaline PH Mechanosensitive Potassium Channel Activity Subcortical Maternal Complex Cytoplasmic Lattice Protein Storage Structural Constituent Of Cytoplasmic Lattice UDP-N-acetylglucosamine Transferase Complex N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Circadian Rhythm Lipid Modification Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Myelin Sheath Adaxonal Region Regulation Of Developmental Process Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Multicellular Organismal Development Regulation Of Synaptic Vesicle Clustering Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Cycle G1/S Phase Transition Postsynaptic Density Assembly	Intermediate Filament Keratin Filament Cytosol Regulation Of JNK Cascade Positive Regulation Of JNK Cascade
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