METTL14 and EXOSC8

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		METTL14	EXOSC8
Name		methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit	exosome component 8
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA N6-methyladenosine Methyltransferase Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	MRNA M(6)A Methyltransferase Activity RNA Binding MRNA Binding Protein Binding S-adenosylmethionine-dependent Methyltransferase Activity Catalytic Activity, Acting On A Nucleic Acid S-adenosyl-L-methionine Binding	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Methylation MRNA Processing MRNA Export From Nucleus Spermatogenesis MRNA Modification Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Cell Differentiation Response To Nutrient Levels Gliogenesis Regulation Of Neuron Differentiation Positive Regulation Of Translation MRNA Stabilization MRNA Destabilization Negative Regulation Of Hematopoietic Progenitor Cell Differentiation	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		Processing of Capped Intron-Containing Pre-mRNA	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		3 interacting genes: CFTR EXOSC8 STUB1	112 interacting genes: AEN ANKHD1 ATF2 C22orf39 CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36
Entrez ID		57721	11340
HPRD ID		13879	09351
Ensembl ID		ENSG00000145388	ENSG00000120699
Uniprot IDs		Q9HCE5	Q96B26
PDB IDs		5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 6TTP 6TTT 6TTV 6TTW 6TTX 6TU1 6Y4G 7ACD 7NHG 7NHH 7NHI 7NHJ 7NHV 7NI7 7NI8 7NI9 7NIA 7NID 7O08 7O09 7O0L 7O0M 7O0P 7O0Q 7O0R 7O27 7O28 7O29 7O2E 7O2F 7O2H 7O2I 7O2X 7OED 7OEE 7OEF 7OEG 7OEH 7OEI 7OEJ 7OEK 7OEL 7OEM 7OQL 7OQO 7OQP 7RX6 7RX7 7RX8 8BN8 9G4S 9G4U 9G4W	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
GO Terms Enriched among Interactors		Protein-folding Chaperone Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Chaperone-mediated Protein Complex Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Vascular Associated Smooth Muscle Contraction U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Positive Regulation Of Enamel Mineralization Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Chaperone-mediated Autophagy Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation TPR Domain Binding U4 SnRNA 3'-end Processing Enzyme Binding Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Vascular Associated Smooth Muscle Contraction RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cellular Response To Misfolded Protein TRNA Decay Nuclear MRNA Surveillance Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Negative Regulation Of Vasoconstriction Response To Misfolded Protein Golgi-associated Vesicle Membrane Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Cellular Response To Forskolin	RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding