METTL14

Description		methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA N6-methyladenosine Methyltransferase Complex
	Molecular Function	MRNA M(6)A Methyltransferase Activity RNA Binding MRNA Binding Protein Binding S-adenosylmethionine-dependent Methyltransferase Activity Catalytic Activity, Acting On A Nucleic Acid S-adenosyl-L-methionine Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Methylation MRNA Processing MRNA Export From Nucleus Spermatogenesis MRNA Modification Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Cell Differentiation Response To Nutrient Levels Gliogenesis Regulation Of Neuron Differentiation Positive Regulation Of Translation MRNA Stabilization MRNA Destabilization Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
Pathways		Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: CFTR EXOSC8 STUB1
Entrez ID		57721
HPRD ID		13879
Ensembl ID		ENSG00000145388
Uniprot IDs		Q9HCE5
PDB IDs		5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 6TTP 6TTT 6TTV 6TTW 6TTX 6TU1 6Y4G 7ACD 7NHG 7NHH 7NHI 7NHJ 7NHV 7NI7 7NI8 7NI9 7NIA 7NID 7O08 7O09 7O0L 7O0M 7O0P 7O0Q 7O0R 7O27 7O28 7O29 7O2E 7O2F 7O2H 7O2I 7O2X 7OED 7OEE 7OEF 7OEG 7OEH 7OEI 7OEJ 7OEK 7OEL 7OEM 7OQL 7OQO 7OQP 7RX6 7RX7 7RX8 8BN8 9G4S 9G4U 9G4W
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Chaperone-mediated Protein Complex Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Vascular Associated Smooth Muscle Contraction U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Positive Regulation Of Enamel Mineralization Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Chaperone-mediated Autophagy Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation TPR Domain Binding U4 SnRNA 3'-end Processing Enzyme Binding Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Vascular Associated Smooth Muscle Contraction RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cellular Response To Misfolded Protein TRNA Decay Nuclear MRNA Surveillance Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Negative Regulation Of Vasoconstriction Response To Misfolded Protein Golgi-associated Vesicle Membrane Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Cellular Response To Forskolin
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