PCDHB16 and SIL1

Data Source: HiPPIP (Novel)

		PCDHB16	SIL1
Name		protocadherin beta 16	SIL1 nucleotide exchange factor
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Unfolded Protein Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Chemical Synaptic Transmission Nervous System Development Synapse Assembly Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules	Protein Folding Cotranslational Protein Targeting To Membrane Intracellular Protein Transport Protein Transport
GWAS		Height ( 31562340 ) Refractive error ( 32231278 )	Appendicular lean mass ( 33097823 ) Malaria ( 31844061 )
Novel Interactors		2 novel interactors: MMS22L SIL1	5 novel interactors: GHRL NPM1 PCDHB16 RFK SETD7
Interacting Genes		None recorded	6 interacting genes: CCND3 FEM1C HSPA5 SGTB SMAD9 UBQLN1
Entrez ID		57717	64374
HPRD ID		06961	12150
Ensembl ID		ENSG00000272674	ENSG00000120725
Uniprot IDs		Q9NRJ7	A0A0S2Z6B4 Q9H173
PDB IDs		Not available	6LBN 6LEY 8PQL 8Q7R
GO Terms Enriched among Interactors		Adenyl-nucleotide Exchange Factor Activity Cotranslational Protein Targeting To Membrane Nuclear Replication Fork FACT Complex MCM Complex Replication Fork Processing Site Of DNA Damage Protein Localization To Chromatin	Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Cellular Response To Stress Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Folding In Endoplasmic Reticulum Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Negative Regulation Of Store-operated Calcium Channel Activity Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation FMN Biosynthetic Process Positive Regulation Of NAD(P)H Oxidase Activity Riboflavin Kinase Activity Riboflavin Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Cerebellum Structural Organization Regulation Of Endoribonuclease Activity Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate TRC Complex Flavin Adenine Dinucleotide Biosynthetic Process Protein-folding Chaperone Binding Positive Regulation Of Protein Modification Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Synapse Assembly Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Unfolded Protein Binding Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Riboflavin Metabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity