MIER1 and LIG1

Number of citations: 61 (PubMedID 33097091)
Data Source: BioGRID (unspecified method)

		MIER1	LIG1
Name		MIER1 transcriptional regulator	DNA ligase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-containing Complex	Nucleus Nucleoplasm
	Molecular Function	Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Histone Deacetylase Binding	Nucleotide Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Ligase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Positive Regulation Of Canonical NF-kappaB Signal Transduction	DNA Replication Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Mismatch Repair DNA Recombination DNA Damage Response Anatomical Structure Morphogenesis V(D)J Recombination Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication
Pathways		None	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs		None	Bleomycin
Diseases		None	DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Allergic rhinitis ( 30013184 ) Appendicular lean mass ( 33097823 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Lymphocyte percentage of white cells ( 27863252 ) Monocyte count ( 32888494 ) Ulcerative colitis ( 28067908 )	No GWAS studies recorded
Interacting Genes		7 interacting genes: APP CREBBP H3-4 HDAC1 LIG1 SP1 TMEM171	20 interacting genes: CBX3 CDY1 CDYL CDYL2 CEBPA CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 L3MBTL3 MIER1 MRE11 PCNA PHF20 PRKCB RGS2 TUBB3 UHRF1
Entrez ID		57708	3978
HPRD ID		11362	00534
Ensembl ID		ENSG00000198160	ENSG00000105486
Uniprot IDs		Q8N108	A0A8V8TPH8 A0A8V8TQC4 B4DM52 F5GZ28 P18858
PDB IDs		Not available	1X9N 5YY9 6P09 6P0A 6P0B 6P0C 6P0D 6P0E 6Q1V 7KR3 7KR4 7L34 7L35 7QNZ 7QO1 7SUM 7SX5 7SXE 8B8T 8VDN 8VDS 8VDT 8VZL 8VZM 9BS3 9BS4
GO Terms Enriched among Interactors		Chromatin Remodeling Positive Regulation Of Amyloid Precursor Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Host-mediated Perturbation Of Viral Transcription Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Embryonic Digit Morphogenesis P53 Binding Rhythmic Process Host-mediated Perturbation Of Viral Process Transcription Repressor Complex Heterochromatin Okazaki Fragment Processing Involved In Mitotic DNA Replication Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin DNA Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Transcription By RNA Polymerase II Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Krueppel-associated Box Domain Binding Histone Deacetylase Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Modulation Of Process Of Another Organism Host-mediated Perturbation Of Symbiont Process DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Replication, Okazaki Fragment Processing DNA Ligase Activity	Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K9me2/3 Reader Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Replication Fork Regulation Of Metabolic Process Chromatin Binding Peptidyl-lysine Dimethylation Epigenetic Regulation Of Gene Expression Response To Dexamethasone Histone H3K27 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K27me3 Reader Activity Histone H3K9 Methyltransferase Activity Nucleoplasm Identical Protein Binding Transcription Corepressor Activity C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Peptidyl-lysine Methylation Negative Regulation Of Gene Expression DNA Strand Elongation Histone H3 Methyltransferase Activity Protein-lysine N-methyltransferase Activity Nuclear Matrix Response To Glucocorticoid Double-strand Break Repair Via Homologous Recombination Brown Fat Cell Differentiation Granulocyte Differentiation Recombinational Repair Negative Regulation Of Transcription By RNA Polymerase II Response To Corticosteroid