SHTN1 and NME7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		SHTN1	NME7
Description		shootin 1	NME/NM23 family member 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Microtubule Cytoskeleton Lamellipodium Filopodium Axon Growth Cone Cell Leading Edge Cell Projection Perikaryon Axonal Growth Cone Perinuclear Region Of Cytoplasm	Gamma-tubulin Ring Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Protein Binding Kinesin Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Nucleoside Diphosphate Kinase Activity Protein Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Hydrolase Activity
	Biological Process	Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Axonogenesis Cdc42 Protein Signal Transduction Netrin-activated Signaling Pathway Positive Regulation Of Axon Extension Neuron Projection Morphogenesis Cytoplasmic Actin-based Contraction Involved In Cell Motility Endoplasmic Reticulum Polarization Actin Filament Bundle Retrograde Transport Regulation Of Establishment Of Cell Polarity Regulation Of Neuron Migration Positive Regulation Of Neuron Migration	Epithelial Cilium Movement Involved In Extracellular Fluid Movement GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Determination Of Left/right Symmetry Brain Development Regulation Of Microtubule Nucleation Flagellated Sperm Motility Intraciliary Transport Receptor Clustering Cilium Assembly Left/right Pattern Formation Cellular Response To Leukemia Inhibitory Factor
Pathways		Recycling pathway of L1	Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Cortical surface area ( 32963231) Cortical volume ( 32963231) Lysophosphatidylethanolamine levels ( 31551469)	Coronary artery disease ( 29212778) D-dimer levels ( 21502573) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left-handedness ( 32989287) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) QT interval ( 30679814) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 21980494 22672568 30659681 33592630)
Interacting Genes		20 interacting genes: BBOX1 DSCAM ESRRG EXOC6B FABP3 IGL IKBKG LNX1 LNX2 MEGF10 NEDD4 NME7 NRIP1 PCNT PRMT2 TFCP2 TNIP1 TP53BP2 WEE2-AS1 ZCCHC17	74 interacting genes: AMOTL2 ARHGAP9 BTBD6 CARD10 CBY2 CCDC136 CCDC33 CCDC88B CCHCR1 CDC42EP2 CEP72 DDIT4L DDX1 DISC1 DNAI7 EFHC2 FKBP6 FLOT1 FOSL1 FOSL2 GATAD2B GLIS2 GOLGA2 GSC2 HAUS8 IKZF1 IKZF3 INCA1 ISY1-RAB43 KRT18 KRT75 LNX1 MAP4K4 MED11 MED30 MEI4 MEOX2 MYOT NAB2 NEFL NFKBIL1 NIF3L1 NME4 NT5C2 OFD1 PAX4 PIAS2 PICK1 POU6F2 PROSER3 PSMA1 REL RUBCN SHTN1 SNAPIN SNX32 SYCE1 TCF4 TCHP TEKT1 TEPSIN THAP10 TNIP1 TNNI2 TRIM27 TRIM48 TUFT1 YWHAQ ZBTB48 ZNF23 ZNF263 ZNF343 ZNF526 ZNF620
Entrez ID		57698	29922
HPRD ID		11155	11394
Ensembl ID		ENSG00000187164	ENSG00000143156
Uniprot IDs		A0MZ66	Q9Y5B8
PDB IDs			7UNG 8J07
Enriched GO Terms of Interacting Partners?			Protein Binding Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity Regulation Of RNA Metabolic Process Phosphatidylinositol 3-kinase Inhibitor Activity
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