TOR1A and LRRC7

Number of citations of the paper that reports this interaction (PMID 15767459)
42

Data Source:
HPRD (in vivo)

		TOR1A	LRRC7
Gene Name		torsin family 1, member A (torsin A)	leucine rich repeat containing 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Lumen Cytoskeleton Synaptic Vesicle Membrane Cell Junction Transport Vesicle Secretory Granule Growth Cone Cytoplasmic Vesicle Membrane Nuclear Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Cytoplasm Postsynaptic Density Cell Junction Postsynaptic Membrane
	Molecular Function	Protein Binding ATP Binding Cytoskeletal Protein Binding ATPase Activity Kinesin Binding Unfolded Protein Binding Misfolded Protein Binding	Protein Binding
	Biological Process	Protein Deneddylation Response To Oxidative Stress Organelle Organization Nuclear Envelope Organization Cell Adhesion Neuron Projection Development Protein Localization To Nucleus Wound Healing, Spreading Of Cells Intermediate Filament Cytoskeleton Organization Synaptic Vesicle Transport Chaperone Mediated Protein Folding Requiring Cofactor Protein Homooligomerization Regulation Of Dopamine Uptake Involved In Synaptic Transmission Chaperone-mediated Protein Folding ER-associated Misfolded Protein Catabolic Process Nuclear Membrane Organization Chaperone-mediated Protein Transport Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Protein Localization To Cell Surface
Pathways
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 21784300) Hypertension risk in short sleep duration ( 22322875) Obesity-related traits ( 23251661) Orofacial clefts ( 22419666)
Protein-Protein Interactions		7 interactors: KRTAP10-7 LMNA LRRC7 SNCA TOR1AIP1 TOR1AIP2 TOR1B	11 interactors: ACTN2 ACTN4 BAI1 CAMK2A CAMK2G CDH2 CNKSR2 CTNND2 HOMEZ NQO2 TOR1A
Entrez ID		1861	57554
HPRD ID		06897	09930
Ensembl ID		ENSG00000136827	ENSG00000033122
Uniprot IDs		B3KPA1 O14656	Q96NW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Envelope Organization Nuclear Membrane Organization Endomembrane System Organization Nucleus Organization Membrane Organization Positive Regulation Of ATPase Activity Positive Regulation Of Hydrolase Activity Regulation Of ATPase Activity Endoplasmic Reticulum Organization Organelle Organization Positive Regulation Of Catalytic Activity Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Sterol Regulatory Element Binding Protein Import Into Nucleus Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Response To Unfolded Protein Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Catalytic Activity Protein Localization To Nucleus Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Iron(II) Ion Cellular Response To Copper Ion Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Cell Aging Regulation Of Dopamine Uptake Involved In Synaptic Transmission Mitotic Nuclear Envelope Reassembly Positive Regulation Of Metabolic Process Regulation Of Oxidative Phosphorylation Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Dopamine Transport Nuclear Envelope Reassembly Regulation Of Glutamate Secretion Dopamine Biosynthetic Process Negative Regulation Of Monooxygenase Activity Neurotransmitter Uptake Regulation Of Cellular Respiration Microglial Cell Activation Extracellular Fibril Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Synaptic Transmission, Dopaminergic SREBP Signaling Pathway	Regulation Of Ion Transport Regulation Of Protein Localization To Cell Surface Regulation Of Cellular Response To Heat Positive Regulation Of Ion Transport Cell Junction Assembly Cell-cell Junction Organization Synaptic Transmission Cell Adhesion Positive Regulation Of Transport Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Synaptic Transmission Cellular Response To Heat Platelet Degranulation Cell-cell Signaling Positive Regulation Of Ion Transmembrane Transport Adherens Junction Organization Protein Oligomerization Cellular Component Assembly Positive Regulation Of Endocytosis Regulation Of Signaling Response To Heat Establishment Of Localization In Cell Protein Localization To Tight Junction Positive Regulation Of Synaptic Vesicle Endocytosis Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Pinocytosis ER-associated Misfolded Protein Catabolic Process Secretion By Cell Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Sodium:proton Antiporter Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cellular Response To Interferon-gamma Nuclear Membrane Organization Wound Healing G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Plasticity Regulation Of Synaptic Vesicle Endocytosis Regulation Of Sodium:proton Antiporter Activity Microspike Assembly Peroxisome Proliferator Activated Receptor Signaling Pathway Secretion Response To Interferon-gamma Cellular Localization Regulation Of Relaxation Of Cardiac Muscle Regulation Of Endocytosis Response To Temperature Stimulus Regulation Of Calcium Ion Transport Response To Wounding
Tagcloud ?		circuits cns cre deltae discrete disrupts dystonia dystonic dyt1 envelope flox hrd1 hypofunction lumen milder movements nestin neurodegeneration neurodevelopmental overtly perinuclear raise reticular sensorimotor striking stymied torsina twisting underpinnings
Tagcloud (Difference) ?		circuits cns cre deltae discrete disrupts dystonia dystonic dyt1 envelope flox hrd1 hypofunction lumen milder movements nestin neurodegeneration neurodevelopmental overtly perinuclear raise reticular sensorimotor striking stymied torsina twisting underpinnings
Tagcloud (Intersection) ?