TOR1A

Gene Name		torsin family 1, member A (torsin A)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Lumen Cytoskeleton Synaptic Vesicle Membrane Cell Junction Transport Vesicle Secretory Granule Growth Cone Cytoplasmic Vesicle Membrane Nuclear Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Cytoskeletal Protein Binding ATPase Activity Kinesin Binding Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	Protein Deneddylation Response To Oxidative Stress Organelle Organization Nuclear Envelope Organization Cell Adhesion Neuron Projection Development Protein Localization To Nucleus Wound Healing, Spreading Of Cells Intermediate Filament Cytoskeleton Organization Synaptic Vesicle Transport Chaperone Mediated Protein Folding Requiring Cofactor Protein Homooligomerization Regulation Of Dopamine Uptake Involved In Synaptic Transmission Chaperone-mediated Protein Folding ER-associated Misfolded Protein Catabolic Process Nuclear Membrane Organization Chaperone-mediated Protein Transport Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Protein Localization To Cell Surface
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: KRTAP10-7 LMNA LRRC7 SNCA TOR1AIP1 TOR1AIP2 TOR1B
Entrez ID		1861
HPRD ID		06897
Ensembl ID		ENSG00000136827
Uniprot IDs		B3KPA1 O14656
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Envelope Organization Nuclear Membrane Organization Endomembrane System Organization Nucleus Organization Membrane Organization Positive Regulation Of ATPase Activity Positive Regulation Of Hydrolase Activity Regulation Of ATPase Activity Endoplasmic Reticulum Organization Organelle Organization Positive Regulation Of Catalytic Activity Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Sterol Regulatory Element Binding Protein Import Into Nucleus Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Response To Unfolded Protein Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Catalytic Activity Protein Localization To Nucleus Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Iron(II) Ion Cellular Response To Copper Ion Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Cell Aging Regulation Of Dopamine Uptake Involved In Synaptic Transmission Mitotic Nuclear Envelope Reassembly Positive Regulation Of Metabolic Process Regulation Of Oxidative Phosphorylation Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Dopamine Transport Nuclear Envelope Reassembly Regulation Of Glutamate Secretion Dopamine Biosynthetic Process Negative Regulation Of Monooxygenase Activity Neurotransmitter Uptake Regulation Of Cellular Respiration Microglial Cell Activation Extracellular Fibril Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Synaptic Transmission, Dopaminergic SREBP Signaling Pathway
Tagcloud ?		circuits cns cre deltae discrete disrupts dystonia dystonic dyt1 envelope flox hrd1 hypofunction lumen milder movements nestin neurodegeneration neurodevelopmental overtly perinuclear raise reticular sensorimotor striking stymied torsina twisting underpinnings