NUFIP2 and PCSK5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		NUFIP2	PCSK5
Description		nuclear FMR1 interacting protein 2	proprotein convertase subtilisin/kexin type 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Nuclear Body	Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Trans-Golgi Network Endomembrane System Membrane
	Molecular Function	RNA Binding Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Peptide Binding
	Biological Process		Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Proteolysis Cell-cell Signaling Heart Development Female Pregnancy Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Secretion By Cell Plasma Lipoprotein Particle Remodeling Limb Morphogenesis Peptide Biosynthetic Process Embryonic Digestive Tract Development Embryonic Skeletal System Development Cytokine Precursor Processing
Pathways			NGF processing Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Apolipoprotein B levels ( 32203549) Depression ( 29700475) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting glucose ( 34059833) Headache ( 29397368) Heel bone mineral density ( 30598549) White blood cell count ( 32888494)	A body shape index ( 34021172) Alzheimer's disease progression score ( 29860282) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Ankylosing spondylitis ( 30946743) Apolipoprotein B levels ( 32203549) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Height ( 20881960 31562340 28552196 23563607 25282103) Hip circumference adjusted for BMI ( 34021172) Hypotension and cognitive impairment ( 31362389) Inflammatory bowel disease ( 27569725) Intraocular pressure ( 31959993 29785010 30054594) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lead levels ( 26025379) Low density lipoprotein cholesterol levels ( 32154731) Male fertility ( 22633400) Metabolite levels (5-HIAA) ( 23319000) Pursuit maintenance gain ( 29064472) Response to fenofibrate (adiponectin levels) ( 23149075) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Systemic sclerosis ( 30247649) Takayasu arteritis ( 25604533) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Vascular brain injury ( 25188341) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Weight ( 34074324)
Interacting Genes		140 interacting genes: ADAMTSL4 AGRN ALPP AMOT CHRD COMP COXFA4L2 CRELD1 CRK CYP21A2 CYSRT1 DKK3 EFEMP1 EFEMP2 EGFL7 ESM1 FBLN1 FBLN2 FBLN5 FHL5 FMR1 FUCA2 GABARAP GABARAPL1 GAPDH GRN HNRNPC ICOS KPRP KRT31 KRT37 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1B LCE1D LCE1F LCE2B LCE2C LCE2D LCE3C LCE4A LCE5A LGALS13 LGALS8 LTBP3 LTBP4 MDFI MEGF11 MEGF6 MIR1-1 MIR106B MIR107 MIR128-1 MIR128-2 MIR138-2 MIR15B MIR17 MIR18A MIR19A MIR200C MIR205 MIR20B MIR21 MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR7-3 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NBPF19 NELL1 NOTCH2NLA NOTCH3 OGT PCSK5 PEAR1 PEX5 PRDX5 RGS17 RGS19 RGS20 SLC22A17 SPRY2 STAB1 STAT3 STMN4 SYNPO TNFRSF4 TRAF1 TRIM42 TRIM55 TRIM63 VWF YPEL3 YWHAG	70 interacting genes: ADAMTSL4 AMH APPBP2 ATN1 C17orf50 C22orf39 CACNA1A CCDC33 CREB5 CYSRT1 DBF4B DOCK2 FAM86C1P FARS2 FRS3 GLRX3 GUCD1 HOXA1 HOXB9 INCA1 ITGA6 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-9 LCE1D LCE1F LCE2C LCE3A LCE3C LCE3D MDFI MEOX2 NBPF19 NOTCH2NLA NR1D2 NR4A3 NUFIP2 OTX1 PCSK6 PLSCR4 PMCH POU4F2 PTPRM REN SHFL SMCP SPRY1 SSC4D STK16 TEKT4 TLE5 TRAF4 TRIB3 TRIM42 TRIP13 USP54 VGLL3 ZNF547 ZNF655 ZNF837
Entrez ID		57532	5125
HPRD ID		11764	08985
Ensembl ID		ENSG00000108256	ENSG00000099139
Uniprot IDs		Q7Z417	A0A669KA35 Q92824
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Intermediate Filament Keratin Filament Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MiRNA-mediated Gene Silencing By Inhibition Of Translation Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Regulation Of MRNA Stability Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Epidermis Development Extracellular Space Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Keratinization Regulation Of Translation Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Extracellular Matrix Structural Constituent Negative Regulation Of Interleukin-6-mediated Signaling Pathway	Intermediate Filament Keratin Filament Epidermis Development Keratinization Identical Protein Binding Tissue Development Protein Binding
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