NUFIP2 and PRDX5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NUFIP2	PRDX5
Description		nuclear FMR1 interacting protein 2	peroxiredoxin 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Nuclear Body	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	RNA Polymerase III Transcription Regulatory Region Sequence-specific DNA Binding Peroxidase Activity Signaling Receptor Binding Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Peroxynitrite Reductase Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process		Inflammatory Response Response To Oxidative Stress Negative Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Oxidoreductase Activity Regulation Of Apoptosis Involved In Tissue Homeostasis Cellular Oxidant Detoxification Reactive Nitrogen Species Metabolic Process
Pathways
Drugs			Auranofin Diminazene
Diseases
GWAS		Age at first birth ( 34211149) Apolipoprotein B levels ( 32203549) Depression ( 29700475) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting glucose ( 34059833) Headache ( 29397368) Heel bone mineral density ( 30598549) White blood cell count ( 32888494)	Alopecia areata ( 20596022 25608926) Crohn's disease ( 21102463 28067908) Multiple sclerosis ( 24076602 31604244) Psoriasis ( 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Psoriasis vulgaris ( 26626624) Sarcoidosis ( 22837380) Vitiligo ( 27723757)
Interacting Genes		140 interacting genes: ADAMTSL4 AGRN ALPP AMOT CHRD COMP COXFA4L2 CRELD1 CRK CYP21A2 CYSRT1 DKK3 EFEMP1 EFEMP2 EGFL7 ESM1 FBLN1 FBLN2 FBLN5 FHL5 FMR1 FUCA2 GABARAP GABARAPL1 GAPDH GRN HNRNPC ICOS KPRP KRT31 KRT37 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1B LCE1D LCE1F LCE2B LCE2C LCE2D LCE3C LCE4A LCE5A LGALS13 LGALS8 LTBP3 LTBP4 MDFI MEGF11 MEGF6 MIR1-1 MIR106B MIR107 MIR128-1 MIR128-2 MIR138-2 MIR15B MIR17 MIR18A MIR19A MIR200C MIR205 MIR20B MIR21 MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR7-3 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NBPF19 NELL1 NOTCH2NLA NOTCH3 OGT PCSK5 PEAR1 PEX5 PRDX5 RGS17 RGS19 RGS20 SLC22A17 SPRY2 STAB1 STAT3 STMN4 SYNPO TNFRSF4 TRAF1 TRIM42 TRIM55 TRIM63 VWF YPEL3 YWHAG	10 interacting genes: APP CCDC90B CDKN2D CLK1 ERBB2 ERBB3 ERBB4 NUFIP2 PEX5 SMCP
Entrez ID		57532	25824
HPRD ID		11764	05958
Ensembl ID		ENSG00000108256	ENSG00000126432
Uniprot IDs		Q7Z417	P30044
PDB IDs			1H4O 1HD2 1OC3 1URM 2VL2 2VL3 2VL9 3MNG 4K7I 4K7N 4K7O 4MMM
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Intermediate Filament Keratin Filament Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MiRNA-mediated Gene Silencing By Inhibition Of Translation Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Regulation Of MRNA Stability Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Epidermis Development Extracellular Space Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Keratinization Regulation Of Translation Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Extracellular Matrix Structural Constituent Negative Regulation Of Interleukin-6-mediated Signaling Pathway	ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Neuregulin Receptor Activity Receptor Complex ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Glial Cell Development Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Growth ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Neuron Differentiation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade Peripheral Nervous System Development Protein Kinase Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Forebrain Neuron Differentiation Regulation Of MAPK Cascade Synapse Organization Kinase Activity Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Growth Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Basolateral Plasma Membrane Heart Development Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Regulation Of ERK1 And ERK2 Cascade Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Localization To Synapse Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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