NUFIP2 and LTBP4

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		NUFIP2	LTBP4
Description		nuclear FMR1 interacting protein 2	latent transforming growth factor beta binding protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Nuclear Body	Microfibril Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	RNA Binding Protein Binding	Transforming Growth Factor Beta Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Growth Factor Binding Transforming Growth Factor Beta Binding
	Biological Process		Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hormone Secretion Elastic Fiber Assembly
Pathways			Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs
Drugs
Diseases			Cutis laxa with severe pulmonary, gastrointestinal, and urinary abnormalities; Urban-Rifkin-Davis syndrome
GWAS		Age at first birth ( 34211149) Apolipoprotein B levels ( 32203549) Depression ( 29700475) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting glucose ( 34059833) Headache ( 29397368) Heel bone mineral density ( 30598549) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1/FVC) ( 26635082 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Red blood cell count ( 32888494)
Interacting Genes		140 interacting genes: ADAMTSL4 AGRN ALPP AMOT CHRD COMP COXFA4L2 CRELD1 CRK CYP21A2 CYSRT1 DKK3 EFEMP1 EFEMP2 EGFL7 ESM1 FBLN1 FBLN2 FBLN5 FHL5 FMR1 FUCA2 GABARAP GABARAPL1 GAPDH GRN HNRNPC ICOS KPRP KRT31 KRT37 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1B LCE1D LCE1F LCE2B LCE2C LCE2D LCE3C LCE4A LCE5A LGALS13 LGALS8 LTBP3 LTBP4 MDFI MEGF11 MEGF6 MIR1-1 MIR106B MIR107 MIR128-1 MIR128-2 MIR138-2 MIR15B MIR17 MIR18A MIR19A MIR200C MIR205 MIR20B MIR21 MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR7-3 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NBPF19 NELL1 NOTCH2NLA NOTCH3 OGT PCSK5 PEAR1 PEX5 PRDX5 RGS17 RGS19 RGS20 SLC22A17 SPRY2 STAB1 STAT3 STMN4 SYNPO TNFRSF4 TRAF1 TRIM42 TRIM55 TRIM63 VWF YPEL3 YWHAG	16 interacting genes: ATN1 ATXN7 CACNA1A CRKL CRY1 CTDSP1 FBLN1 FRAT1 GFI1B HOXA1 ITSN2 MBD1 NUFIP2 RAC1 SHANK3 TGFB1
Entrez ID		57532	8425
HPRD ID		11764	05274
Ensembl ID		ENSG00000108256	ENSG00000090006
Uniprot IDs		Q7Z417	A0A0C4DH07 B3KXY6 Q8N2S1
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Intermediate Filament Keratin Filament Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MiRNA-mediated Gene Silencing By Inhibition Of Translation Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Regulation Of MRNA Stability Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Epidermis Development Extracellular Space Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Keratinization Regulation Of Translation Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Extracellular Matrix Structural Constituent Negative Regulation Of Interleukin-6-mediated Signaling Pathway	Nuclear Matrix Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Interleukin-23 Production Postsynaptic Specialization Assembly Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Positive Regulation Of Cell-substrate Adhesion Postsynaptic Specialization Organization Regulation Of Leukocyte Migration Helper T Cell Diapedesis Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Adhesion Regulation Of Cellular Localization Dendrite Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Migration Negative Regulation Of Metabolic Process Positive Regulation Of Cell Motility Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Central Nervous System Neuron Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Protein Localization To Membrane Regulation Of Cell-substrate Adhesion Establishment Or Maintenance Of Cell Polarity Blue Light Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Transformation Of Host Cell By Virus Cochlea Morphogenesis Semicircular Canal Formation Abducens Nerve Formation Inner Ear Development Optokinetic Behavior Positive Regulation Of Ovarian Follicle Development Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Interleukin-23 Production Negative Regulation Of Endocytosis Regulation Of Cell Development Regulation Of Fibroblast Migration Regulation Of ERK5 Cascade
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