PLXNA2 and CEMIP

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		PLXNA2	CEMIP
Description		plexin A2	cell migration inducing hyaluronidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Membrane	Fibrillar Center Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Membrane Nuclear Membrane Clathrin-coated Endocytic Vesicle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Identical Protein Binding	Hyalurononglucosaminidase Activity Protein Binding Hyaluronic Acid Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Clathrin Heavy Chain Binding ER Retention Sequence Binding
	Biological Process	Somitogenesis Cell Surface Receptor Signaling Pathway Nervous System Development Synapse Assembly Anatomical Structure Morphogenesis Neural Tube Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Tube Development Animal Organ Development Centrosome Localization Pharyngeal System Development Limb Bud Formation Semaphorin-plexin Signaling Pathway	Sensory Perception Of Sound Positive Regulation Of Peptidyl-threonine Phosphorylation Hyaluronan Metabolic Process Hyaluronan Biosynthetic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Kinase C Activity
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions	Hyaluronan degradation
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Bitter alcoholic beverage consumption ( 31046077) Cardiac hypertrophy ( 21348951) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) General risk tolerance (MTAG) ( 30643258) Lung cancer in never smokers ( 28604730) Manganese levels ( 26025379) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)	Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) HDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		6 interacting genes: CEMIP DHX37 FNBP4 HACE1 IFT80 UBAP2L	1 interacting genes: PLXNA2
Entrez ID		5362	57214
HPRD ID		03033	10519
Ensembl ID		ENSG00000076356	ENSG00000103888
Uniprot IDs		O75051	Q8WUJ3
PDB IDs		3Q3J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Granule Assembly Regulation Of Stress Granule Assembly Membraneless Organelle Assembly Organelle Assembly Macromolecule Catabolic Process Hyaluronan Biosynthetic Process Hyalurononglucosaminidase Activity Clathrin Heavy Chain Binding Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Peptidyl-threonine Phosphorylation ER Retention Sequence Binding Nuclear Membrane Tooth Eruption Articular Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Protein Localization To Non-motile Cilium Protein Localization To Ciliary Membrane Growth Plate Cartilage Development 9+0 Non-motile Cilium Osteoblast Proliferation Negative Regulation Of Non-canonical Wnt Signaling Pathway Odontoblast Differentiation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Bone Mineralization Involved In Bone Maturation Response To Inositol Cartilage Homeostasis Receptor Localization To Non-motile Cilium Positive Regulation Of Male Gonad Development U3 SnoRNA Binding Hyaluronan Catabolic Process	Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Dibenzo-p-dioxin Catabolic Process Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Tube Development Arachidonate Monooxygenase Activity Insecticide Metabolic Process Response To Diphenyl Ether Ethylene Metabolic Process Cerebellar Granule Cell Precursor Tangential Migration Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Response To Iron(III) Ion Demethylase Activity Dibenzo-p-dioxin Metabolic Process Coumarin Metabolic Process Long-chain Fatty Acid Omega-1 Hydroxylase Activity Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Hindbrain Tangential Cell Migration Long-chain Fatty Acid Omega-hydroxylase Activity Lipid Hydroxylation Response To Phenylpropanoid Retinoic Acid Biosynthetic Process Estrogen 16-alpha-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Response To 2,3,7,8-tetrachlorodibenzodioxine Estrogen 2-hydroxylase Activity Response To Nematode Limb Bud Formation Omega-hydroxylase P450 Pathway Flavonoid Metabolic Process Hydrogen Peroxide Biosynthetic Process Cell Migration In Hindbrain Response To Vitamin A Vitamin D Metabolic Process Semaphorin Receptor Activity Epoxygenase P450 Pathway Hepatocyte Differentiation Semaphorin Receptor Complex Reactive Oxygen Species Biosynthetic Process Steroid Hydroxylase Activity Toxin Metabolic Process Response To Hyperoxia Pharyngeal System Development Response To Immobilization Stress Cellular Response To Copper Ion
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