PLXNA2

Description		plexin A2
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Identical Protein Binding
	Biological Process	Somitogenesis Cell Surface Receptor Signaling Pathway Nervous System Development Synapse Assembly Anatomical Structure Morphogenesis Neural Tube Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Tube Development Animal Organ Development Centrosome Localization Pharyngeal System Development Limb Bud Formation Semaphorin-plexin Signaling Pathway
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Bitter alcoholic beverage consumption ( 31046077) Cardiac hypertrophy ( 21348951) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) General risk tolerance (MTAG) ( 30643258) Lung cancer in never smokers ( 28604730) Manganese levels ( 26025379) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		6 interacting genes: CEMIP DHX37 FNBP4 HACE1 IFT80 UBAP2L
Entrez ID		5362
HPRD ID		03033
Ensembl ID		ENSG00000076356
Uniprot IDs		O75051
PDB IDs		3Q3J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Granule Assembly Regulation Of Stress Granule Assembly Membraneless Organelle Assembly Organelle Assembly Macromolecule Catabolic Process Hyaluronan Biosynthetic Process Hyalurononglucosaminidase Activity Clathrin Heavy Chain Binding Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Peptidyl-threonine Phosphorylation ER Retention Sequence Binding Nuclear Membrane Tooth Eruption Articular Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Protein Localization To Non-motile Cilium Protein Localization To Ciliary Membrane Growth Plate Cartilage Development 9+0 Non-motile Cilium Osteoblast Proliferation Negative Regulation Of Non-canonical Wnt Signaling Pathway Odontoblast Differentiation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Bone Mineralization Involved In Bone Maturation Response To Inositol Cartilage Homeostasis Receptor Localization To Non-motile Cilium Positive Regulation Of Male Gonad Development U3 SnoRNA Binding Hyaluronan Catabolic Process
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