PLXNA2 and DHX37

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		PLXNA2	DHX37
Description		plexin A2	DEAH-box helicase 37
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Nuclear Membrane Small-subunit Processome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Identical Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity U3 SnoRNA Binding
	Biological Process	Somitogenesis Cell Surface Receptor Signaling Pathway Nervous System Development Synapse Assembly Anatomical Structure Morphogenesis Neural Tube Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Tube Development Animal Organ Development Centrosome Localization Pharyngeal System Development Limb Bud Formation Semaphorin-plexin Signaling Pathway	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Brain Development Ribosome Biogenesis Ribosome Assembly Ribosomal Small Subunit Biogenesis Positive Regulation Of Male Gonad Development
Pathways		Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Bitter alcoholic beverage consumption ( 31046077) Cardiac hypertrophy ( 21348951) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) General risk tolerance (MTAG) ( 30643258) Lung cancer in never smokers ( 28604730) Manganese levels ( 26025379) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)	HDL cholesterol levels ( 32203549) Hip circumference ( 28552196) Insulin levels in response to oral glucose tolerance test (120 minutes) ( 29093273)
Interacting Genes		6 interacting genes: CEMIP DHX37 FNBP4 HACE1 IFT80 UBAP2L	56 interacting genes: ATXN1 EIF4ENIF1 KIFAP3 KRT31 MIR1-1 MIR1-2 MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR143 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR199A1 MIR19B1 MIR19B2 MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR25 MIR29A MIR34A MIR34B MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PLXNA2 RGS17 TRIP6
Entrez ID		5362	57647
HPRD ID		03033	10883
Ensembl ID		ENSG00000076356	ENSG00000150990
Uniprot IDs		O75051	Q8IY37
PDB IDs		3Q3J	7MQA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Stress Granule Assembly Regulation Of Stress Granule Assembly Membraneless Organelle Assembly Organelle Assembly Macromolecule Catabolic Process Hyaluronan Biosynthetic Process Hyalurononglucosaminidase Activity Clathrin Heavy Chain Binding Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Peptidyl-threonine Phosphorylation ER Retention Sequence Binding Nuclear Membrane Tooth Eruption Articular Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Protein Localization To Non-motile Cilium Protein Localization To Ciliary Membrane Growth Plate Cartilage Development 9+0 Non-motile Cilium Osteoblast Proliferation Negative Regulation Of Non-canonical Wnt Signaling Pathway Odontoblast Differentiation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Bone Mineralization Involved In Bone Maturation Response To Inositol Cartilage Homeostasis Receptor Localization To Non-motile Cilium Positive Regulation Of Male Gonad Development U3 SnoRNA Binding Hyaluronan Catabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Regulation Of Gene Expression Negative Regulation Of Cell Migration Regulation Of Vasculature Development Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility MRNA Destabilization RNA Destabilization Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability Regulation Of Translation Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Cell Motility Regulation Of Metabolic Process Negative Regulation Of Developmental Process Regulation Of Locomotion Negative Regulation Of Protein Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cellular Response To Growth Factor Stimulus
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