HECW2 and ANAPC11

Number of citations of the paper that reports this interaction (PMID 24163370)
0

Data Source:
BioGRID (enzymatic study)

		HECW2	ANAPC11
Gene Name		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	anaphase promoting complex subunit 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Mitotic Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ANAPC11 FZR1 TP73	27 interactors: ANAPC1 ANAPC10 ANAPC2 CAPN11 CCNB1 CDC16 CDC25A CDC34 CDH1 CUL5 FBXO5 HECW2 KIF18A MAK MLKL NKD2 PTTG1 RNF111 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2K UBE2S UBE2U ZAP70
Entrez ID		57520	51529
HPRD ID		17099	12452
Ensembl ID		ENSG00000138411	ENSG00000141552
Uniprot IDs		Q9P2P5	Q9NYG5
PDB IDs		2LFE
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Negative Regulation Of Transferase Activity Protein K11-linked Ubiquitination Regulation Of Cell Cycle Process Positive Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Protein Polyubiquitination Cell Cycle Regulation Of Protein Ubiquitination Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Proteolysis Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Activation Of Anaphase-promoting Complex Activity	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteolysis Mitotic Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Catabolic Process Mitotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Cycle Process Negative Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Chromosome Segregation Cell Cycle Regulation Of Proteolysis Regulation Of Mitotic Sister Chromatid Separation Protein Metabolic Process Cell Division Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		aml candidate considerable contribute database evolution evolved gata germline heterogeneity heterozygous immunodeficiency leukocytes manifestations marrow mds mesenchymal missense mononuclear narrowing ncbi nonsynonymous nucleotide overlapping polymorphism predisposition r330x suggestive termed	afg3l2 arf1 calgizzarin cki dci dph2l fb1 fxyd6 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa
Tagcloud (Difference) ?		aml candidate considerable contribute database evolution evolved gata germline heterogeneity heterozygous immunodeficiency leukocytes manifestations marrow mds mesenchymal missense mononuclear narrowing ncbi nonsynonymous nucleotide overlapping polymorphism predisposition r330x suggestive termed	afg3l2 arf1 calgizzarin cki dci dph2l fb1 fxyd6 gif gp96 gpr85 hhp2 kpdxm ksp mrps7 ohs osteosarcomas ought p110 phosphoglucoisomerase rpl13a rpl35a s11 sec34 skd3 subtracted subtractive sulphonase tapa
Tagcloud (Intersection) ?