GPR158 and ENKUR

Data Source: HiPPIP (Novel)

		GPR158	ENKUR
Name		G protein-coupled receptor 158	enkurin, TRPC channel interacting protein
Structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Postsynaptic Density Membrane	Acrosomal Vesicle Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection Sperm Principal Piece 9+0 Motile Cilium 9+2 Motile Cilium Axonemal B Tubule Inner Sheath
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Enzyme Activator Activity G Protein-coupled Glycine Receptor Activity	Protein Binding Calmodulin Binding SH3 Domain Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Synapse Organization Cognition Protein Localization To Plasma Membrane	Flagellated Sperm Motility Establishment Of Left/right Asymmetry
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Central corneal thickness ( 32528159 ) Cerebellum white matter volume ( 31530798 ) Diverticular disease ( 30177863 30661054 ) Energy expenditure (24h) ( 28476931 ) Hepatitis C (spontaneous viral clearance) ( 30593799 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Intelligence (MTAG) ( 29326435 ) Intraocular pressure ( 29235454 29617998 ) QRS duration in Tripanosoma cruzi seropositivity ( 24324551 )	No GWAS studies recorded
Novel Interactors		6 novel interactors: ACBD5 APBB1IP ENKUR MASTL MKX PRTFDC1	1 novel interactors: GPR158
Interacting Genes		None recorded	6 interacting genes: CFAP45 LRRK1 LRRK2 PIK3R1 PIK3R2 TRPC5
Entrez ID		57512	219670
HPRD ID		13601	12583
Ensembl ID		ENSG00000151025	ENSG00000151023
Uniprot IDs		Q5T848	A0A087WUX1 Q8TC29
PDB IDs		7EWL 7EWP 7EWR 7SHE 7SHF	7UNG 8J07
GO Terms Enriched among Interactors		Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage Female Meiosis II T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Purine Ribonucleoside Salvage Guanine Metabolic Process GMP Catabolic Process Purine Nucleobase Biosynthetic Process Microtubule Cytoskeleton Establishment Of Left/right Asymmetry Axonemal B Tubule Inner Sheath 9+0 Motile Cilium Purine Nucleoside Monophosphate Catabolic Process Nucleoside Salvage Fatty-acyl-CoA Binding T Cell Receptor Complex Purine Nucleobase Metabolic Process Female Meiotic Nuclear Division Pexophagy	Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding Intracellular Chemical Homeostasis Homeostatic Process Cellular Homeostasis Clathrin Binding GTPase Activator Activity Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Phosphotyrosine Residue Binding Positive Regulation Of Transport Chemical Homeostasis Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Insulin Stimulus Regulation Of Stress Fiber Assembly Positive Regulation Of Intracellular Protein Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Localization To Nucleus Insulin Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion G Protein-coupled Glycine Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cellular Localization B Cell Differentiation Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Regulation Of Protein Localization To Plasma Membrane Regulation Of Nucleocytoplasmic Transport Kinase Regulator Activity Import Into Nucleus Perinuclear Endoplasmic Reticulum Membrane Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Protein Autoubiquitination