GPR158 and ACBD5

		GPR158	ACBD5
Description		G protein-coupled receptor 158	acyl-CoA binding domain containing 5
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GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Postsynaptic Density Membrane	Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Enzyme Activator Activity G Protein-coupled Glycine Receptor Activity	Fatty-acyl-CoA Binding Protein Binding Lipid Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Synapse Organization Cognition Protein Localization To Plasma Membrane	Pexophagy Fatty Acid Metabolic Process Autophagy Fatty Acid Catabolic Process
Pathways			Peroxisomal lipid metabolism RHOA GTPase cycle RHOC GTPase cycle Class I peroxisomal membrane protein import
Drugs
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Central corneal thickness ( 32528159) Cerebellum white matter volume ( 31530798) Diverticular disease ( 30177863 30661054) Energy expenditure (24h) ( 28476931) Hepatitis C (spontaneous viral clearance) ( 30593799) Immune response to smallpox vaccine (IL-6) ( 22542470) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29235454 29617998) QRS duration in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes			4 interacting genes: GRM2 SLC38A7 STX1B TMEM229B
Entrez ID		57512	91452
HPRD ID		13601	12415
Ensembl ID		ENSG00000151025	ENSG00000107897
Uniprot IDs		Q5T848	A0A7I2V2M2 A0A7I2V347 A0A7I2V556 A0A7I2V690 A0A7I2YQE9 B7Z2A7 B7Z2R7 B7Z9D0 Q5T8D3
PDB IDs		7EWL 7EWP 7EWR 7SHE 7SHF	3FLV
Enriched GO Terms of Interacting Partners?		Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage Female Meiosis II T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Purine Ribonucleoside Salvage Guanine Metabolic Process GMP Catabolic Process Purine Nucleobase Biosynthetic Process Microtubule Cytoskeleton Establishment Of Left/right Asymmetry Axonemal B Tubule Inner Sheath 9+0 Motile Cilium Purine Nucleoside Monophosphate Catabolic Process Nucleoside Salvage Fatty-acyl-CoA Binding T Cell Receptor Complex Purine Nucleobase Metabolic Process Female Meiotic Nuclear Division Pexophagy	Positive Regulation Of Neurotransmitter Secretion Axon Modulation Of Chemical Synaptic Transmission L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Regulation Of Neurotransmitter Secretion G Protein-coupled Glycine Receptor Activity Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling Regulation Of Secretion By Cell Regulation Of Secretion Amino Acid Transport Group II Metabotropic Glutamate Receptor Activity Presynaptic Membrane Positive Regulation Of Synaptic Transmission Asparagine Transport L-asparagine Transmembrane Transporter Activity Regulation Of Synaptic Activity Negative Regulation Of Pinocytosis Intracellular Glutamate Homeostasis Postsynaptic Membrane Regulation Of Spontaneous Synaptic Transmission Spontaneous Neurotransmitter Secretion Regulation Of Response To Drug Carboxylic Acid Transport Organic Acid Transport Glutamine Transport L-glutamine Transmembrane Transporter Activity Behavioral Response To Nicotine Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Intracellular Amino Acid Homeostasis Calcium Ion-regulated Exocytosis Of Neurotransmitter Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cell Projection Positive Regulation Of Secretion Synaptic Vesicle Docking Regulation Of Synaptic Vesicle Priming Vesicle Fusion To Plasma Membrane Glutamate Receptor Activity Astrocyte Projection Nuclear Lamina Organic Anion Transport Glutamate Secretion Synaptic Vesicle Membrane Organization G Protein-coupled Receptor Activity Long-term Synaptic Depression G Protein-coupled Glutamate Receptor Signaling Pathway
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