GPR158 and APBB1IP

Data Source: HiPPIP (Novel)

		GPR158	APBB1IP
Name		G protein-coupled receptor 158	amyloid beta precursor protein binding family B member 1 interacting protein
Structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Postsynaptic Density Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium T Cell Receptor Complex Cell Projection Anchoring Junction
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Enzyme Activator Activity G Protein-coupled Glycine Receptor Activity	Protein Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Synapse Organization Cognition Protein Localization To Plasma Membrane	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Signal Transduction Positive Regulation Of Cell Adhesion
Pathways		None	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Central corneal thickness ( 32528159 ) Cerebellum white matter volume ( 31530798 ) Diverticular disease ( 30177863 30661054 ) Energy expenditure (24h) ( 28476931 ) Hepatitis C (spontaneous viral clearance) ( 30593799 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Intelligence (MTAG) ( 29326435 ) Intraocular pressure ( 29235454 29617998 ) QRS duration in Tripanosoma cruzi seropositivity ( 24324551 )	Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 27863252 ) Inflammatory biomarkers ( 22228203 ) Lymphocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 27863252 ) Neutrophil percentage of granulocytes ( 27863252 ) Response to angiotensin II receptor blocker therapy ( 22566498 ) Sum eosinophil basophil counts ( 27863252 ) White blood cell count ( 32888494 ) White blood cell count (basophil) ( 27863252 )
Novel Interactors		6 novel interactors: ACBD5 APBB1IP ENKUR MASTL MKX PRTFDC1	2 novel interactors: GPR158 RAB18
Interacting Genes		None recorded	11 interacting genes: BAG6 EVL GAS7 HRAS NDN PFN1 PRPF40A RAP1A TLX3 VASP ZDHHC17
Entrez ID		57512	54518
HPRD ID		13601	16420
Ensembl ID		ENSG00000151025	ENSG00000077420
Uniprot IDs		Q5T848	Q7Z5R6
PDB IDs		7EWL 7EWP 7EWR 7SHE 7SHF	2MWN 3ZDL
GO Terms Enriched among Interactors		Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage Female Meiosis II T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Purine Ribonucleoside Salvage Guanine Metabolic Process GMP Catabolic Process Purine Nucleobase Biosynthetic Process Microtubule Cytoskeleton Establishment Of Left/right Asymmetry Axonemal B Tubule Inner Sheath 9+0 Motile Cilium Purine Nucleoside Monophosphate Catabolic Process Nucleoside Salvage Fatty-acyl-CoA Binding T Cell Receptor Complex Purine Nucleobase Metabolic Process Female Meiotic Nuclear Division Pexophagy	Regulation Of Ruffle Assembly Developmental Process Positive Regulation Of Actin Filament Polymerization GDP Binding Modulation Of Chemical Synaptic Transmission Profilin Binding Positive Regulation Of Protein Polymerization Glutamatergic Synapse Positive Regulation Of Ruffle Assembly Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Respiratory Gaseous Exchange By Respiratory System Neurotrophin Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Regulation Of Cell Projection Assembly System Development Brain Development Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Small GTPase-mediated Signal Transduction Neuron Projection Morphogenesis Cell Projection Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Positive Regulation Of Actin Filament Bundle Assembly Protein Homotetramerization Actin Polymerization Or Depolymerization Perforant Pathway To Dendrate Granule Cell Synapse G Protein-coupled Glycine Receptor Activity Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Epithelial Cell Migration G Protein Activity Regulation Of Cell Projection Organization Regulation Of Biological Quality GTPase Complex Response To Antineoplastic Agent Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Postsynaptic Golgi Apparatus