AMIGO1 and AMIGO2

Number of citations of the paper that reports this interaction (PubMedID 12629050)
35

Data Source:
HPRD (in vivo, in vitro)

		AMIGO1	AMIGO2
Description		adhesion molecule with Ig like domain 1	adhesion molecule with Ig like domain 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Neuronal Cell Body Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Pericellular Basket	Nucleus Plasma Membrane Membrane
	Molecular Function	Protein Binding Potassium Channel Regulator Activity	Protein Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Nervous System Development Axonogenesis Axonal Fasciculation Brain Development Positive Regulation Of Neuron Projection Development Cell Differentiation Myelination Positive Regulation Of Axonogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Nervous System Development Positive Regulation Of Synapse Assembly Neuron Projection Fasciculation Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Response To L-glutamate	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Brain Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Synapse Assembly
Pathways			RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Intelligence (MTAG) ( 29326435) LDL cholesterol levels ( 32203549) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)	Blood protein levels ( 30072576)
Interacting Genes		35 interacting genes: ADIPOQ AMIGO2 AMIGO3 ANKRD46 ASGR1 BNIP3 C3orf52 CLDN11 CXCL9 EDDM3B GJB2 HHATL IGFBP5 LMO3 MALL NINJ2 NKG7 PGA4 PGAP2 PLPP6 PROM2 PTTG1IP RPRM SELENOK SLC38A1 SLC38A7 SLC41A1 STX8 TM4SF5 TMEM50B TMEM60 TMEM79 TNMD TSPO UPK2	4 interacting genes: AMIGO1 AMIGO3 CACNA1A TMED8
Entrez ID		57463	347902
HPRD ID		11129	16483
Ensembl ID		ENSG00000181754	ENSG00000139211
Uniprot IDs		Q86WK6	Q86SJ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Cholesterol Binding Glutamine Transport L-glutamine Transmembrane Transporter Activity	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Synapse Assembly Positive Regulation Of Cell Junction Assembly Regulation Of Synapse Assembly Pericellular Basket Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Brain Development Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Regulation Of Synapse Organization Cellular Response To L-glutamate Neuronal Cell Body Calcium Ion Import Across Plasma Membrane Voltage-gated Calcium Channel Complex High Voltage-gated Calcium Channel Activity Calcium Ion Import Into Cytosol Cell-cell Adhesion Positive Regulation Of Cellular Component Biogenesis Response To L-glutamate Regulation Of Neuron Projection Development Neuronal Cell Body Membrane Axonal Fasciculation Neuron Projection Fasciculation Regulation Of Nervous System Development Positive Regulation Of Potassium Ion Transmembrane Transport Nervous System Development Voltage-gated Calcium Channel Activity Calcium Ion Import Positive Regulation Of Potassium Ion Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization
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