AMIGO1 and TM4SF5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AMIGO1	TM4SF5
Description		adhesion molecule with Ig like domain 1	transmembrane 4 L six family member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Neuronal Cell Body Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Pericellular Basket	Lysosome Lysosomal Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding Potassium Channel Regulator Activity	Protein Binding Arginine Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Nervous System Development Axonogenesis Axonal Fasciculation Brain Development Positive Regulation Of Neuron Projection Development Cell Differentiation Myelination Positive Regulation Of Axonogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Nervous System Development Positive Regulation Of Synapse Assembly Neuron Projection Fasciculation Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Response To L-glutamate	Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Intelligence (MTAG) ( 29326435) LDL cholesterol levels ( 32203549) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)	Initial alcohol sensitivity ( 30276832) Metabolite levels ( 22916037) Triglyceride levels ( 32203549) Triglycerides ( 25961943)
Interacting Genes		35 interacting genes: ADIPOQ AMIGO2 AMIGO3 ANKRD46 ASGR1 BNIP3 C3orf52 CLDN11 CXCL9 EDDM3B GJB2 HHATL IGFBP5 LMO3 MALL NINJ2 NKG7 PGA4 PGAP2 PLPP6 PROM2 PTTG1IP RPRM SELENOK SLC38A1 SLC38A7 SLC41A1 STX8 TM4SF5 TMEM50B TMEM60 TMEM79 TNMD TSPO UPK2	1 interacting genes: AMIGO1
Entrez ID		57463	9032
HPRD ID		11129	06877
Ensembl ID		ENSG00000181754	ENSG00000142484
Uniprot IDs		Q86WK6	O14894
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Cholesterol Binding Glutamine Transport L-glutamine Transmembrane Transporter Activity	Pericellular Basket Response To L-glutamate Positive Regulation Of Potassium Ion Transmembrane Transport Neuronal Cell Body Membrane Axonal Fasciculation Cellular Response To L-glutamate Neuron Projection Fasciculation Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Potassium Ion Transport Potassium Channel Regulator Activity Neuron Recognition Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Recognition Response To Amino Acid Positive Regulation Of Synapse Assembly Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Axonogenesis Regulation Of Potassium Ion Transport Cellular Response To Amino Acid Stimulus Positive Regulation Of Cell Junction Assembly Myelination Axon Ensheathment Voltage-gated Potassium Channel Complex Positive Regulation Of Cation Transmembrane Transport Perikaryon Regulation Of Axonogenesis Positive Regulation Of Neuron Projection Development Axonogenesis Regulation Of Synapse Assembly Positive Regulation Of Monoatomic Ion Transport Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Neurogenesis Brain Development Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Neuron Projection Morphogenesis Regulation Of Monoatomic Cation Transmembrane Transport Cell Projection Morphogenesis Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synapse Organization Neuron Projection Neuronal Cell Body Regulation Of Neurogenesis Regulation Of Metal Ion Transport Positive Regulation Of Cell Projection Organization Axon Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Development Regulation Of Neuron Projection Development
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