AMIGO2 and TMED8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AMIGO2	TMED8
Description		adhesion molecule with Ig like domain 2	transmembrane p24 trafficking protein family member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Brain Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Synapse Assembly
Pathways		RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		4 interacting genes: AMIGO1 AMIGO3 CACNA1A TMED8	32 interacting genes: ADTRP AMIGO2 APOL2 ARL6IP1 C10orf67 CIAO2A CMTM5 CMTM6 CYB561D1 DEFB129 DERL1 DGAT2L6 EI24 H4C7 LAPTM4A MDK MMGT1 MRPL41 MRPS18B MTIF3 NDUFA12 REEP6 SERP2 STX8 SUSD3 TMEM115 TMEM121 TMEM218 TMEM254 TRAM1L1 UNC50 ZDHHC16
Entrez ID		347902	283578
HPRD ID		16483	18201
Ensembl ID		ENSG00000139211	ENSG00000100580
Uniprot IDs		Q86SJ2	Q6PL24
PDB IDs
Enriched GO Terms of Interacting Partners?		Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Synapse Assembly Positive Regulation Of Cell Junction Assembly Regulation Of Synapse Assembly Pericellular Basket Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Brain Development Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Regulation Of Synapse Organization Cellular Response To L-glutamate Neuronal Cell Body Calcium Ion Import Across Plasma Membrane Voltage-gated Calcium Channel Complex High Voltage-gated Calcium Channel Activity Calcium Ion Import Into Cytosol Cell-cell Adhesion Positive Regulation Of Cellular Component Biogenesis Response To L-glutamate Regulation Of Neuron Projection Development Neuronal Cell Body Membrane Axonal Fasciculation Neuron Projection Fasciculation Regulation Of Nervous System Development Positive Regulation Of Potassium Ion Transmembrane Transport Nervous System Development Voltage-gated Calcium Channel Activity Calcium Ion Import Positive Regulation Of Potassium Ion Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization	Endoplasmic Reticulum Membrane
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