AMIGO2 and AMIGO1

Number of citations of the paper that reports this interaction (PubMedID 12629050)
35

Data Source:
HPRD (in vivo, in vitro)

		AMIGO2	AMIGO1
Description		adhesion molecule with Ig like domain 2	adhesion molecule with Ig like domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Neuronal Cell Body Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Pericellular Basket
	Molecular Function	Protein Binding	Protein Binding Potassium Channel Regulator Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Brain Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Synapse Assembly	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Nervous System Development Axonogenesis Axonal Fasciculation Brain Development Positive Regulation Of Neuron Projection Development Cell Differentiation Myelination Positive Regulation Of Axonogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Nervous System Development Positive Regulation Of Synapse Assembly Neuron Projection Fasciculation Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Response To L-glutamate
Pathways		RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Chronic kidney disease ( 20383146) Intelligence (MTAG) ( 29326435) LDL cholesterol levels ( 32203549) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)
Interacting Genes		4 interacting genes: AMIGO1 AMIGO3 CACNA1A TMED8	35 interacting genes: ADIPOQ AMIGO2 AMIGO3 ANKRD46 ASGR1 BNIP3 C3orf52 CLDN11 CXCL9 EDDM3B GJB2 HHATL IGFBP5 LMO3 MALL NINJ2 NKG7 PGA4 PGAP2 PLPP6 PROM2 PTTG1IP RPRM SELENOK SLC38A1 SLC38A7 SLC41A1 STX8 TM4SF5 TMEM50B TMEM60 TMEM79 TNMD TSPO UPK2
Entrez ID		347902	57463
HPRD ID		16483	11129
Ensembl ID		ENSG00000139211	ENSG00000181754
Uniprot IDs		Q86SJ2	Q86WK6
PDB IDs
Enriched GO Terms of Interacting Partners?		Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Synapse Assembly Positive Regulation Of Cell Junction Assembly Regulation Of Synapse Assembly Pericellular Basket Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Brain Development Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Regulation Of Synapse Organization Cellular Response To L-glutamate Neuronal Cell Body Calcium Ion Import Across Plasma Membrane Voltage-gated Calcium Channel Complex High Voltage-gated Calcium Channel Activity Calcium Ion Import Into Cytosol Cell-cell Adhesion Positive Regulation Of Cellular Component Biogenesis Response To L-glutamate Regulation Of Neuron Projection Development Neuronal Cell Body Membrane Axonal Fasciculation Neuron Projection Fasciculation Regulation Of Nervous System Development Positive Regulation Of Potassium Ion Transmembrane Transport Nervous System Development Voltage-gated Calcium Channel Activity Calcium Ion Import Positive Regulation Of Potassium Ion Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization	Membrane Cholesterol Binding Glutamine Transport L-glutamine Transmembrane Transporter Activity
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