AMIGO1 and PGA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AMIGO1	PGA4
Description		adhesion molecule with Ig like domain 1	pepsinogen A4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Neuronal Cell Body Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Pericellular Basket	Extracellular Region Extracellular Exosome Multivesicular Body Lumen
	Molecular Function	Protein Binding Potassium Channel Regulator Activity	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Nervous System Development Axonogenesis Axonal Fasciculation Brain Development Positive Regulation Of Neuron Projection Development Cell Differentiation Myelination Positive Regulation Of Axonogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Nervous System Development Positive Regulation Of Synapse Assembly Neuron Projection Fasciculation Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Response To L-glutamate	Proteolysis Digestion
Pathways			Surfactant metabolism
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Intelligence (MTAG) ( 29326435) LDL cholesterol levels ( 32203549) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)
Interacting Genes		35 interacting genes: ADIPOQ AMIGO2 AMIGO3 ANKRD46 ASGR1 BNIP3 C3orf52 CLDN11 CXCL9 EDDM3B GJB2 HHATL IGFBP5 LMO3 MALL NINJ2 NKG7 PGA4 PGAP2 PLPP6 PROM2 PTTG1IP RPRM SELENOK SLC38A1 SLC38A7 SLC41A1 STX8 TM4SF5 TMEM50B TMEM60 TMEM79 TNMD TSPO UPK2	9 interacting genes: AMIGO1 C16orf92 CD74 FNDC9 HHLA2 PVR SPAG4 STOM TMEM106C
Entrez ID		57463	643847
HPRD ID		11129	18942
Ensembl ID		ENSG00000181754	ENSG00000229183
Uniprot IDs		Q86WK6	A0A1S5UZ02 B7Z719 P0DJD7
PDB IDs			1FLH 1PSN 1PSO 1QRP 3UTL
Enriched GO Terms of Interacting Partners?		Membrane Cholesterol Binding Glutamine Transport L-glutamine Transmembrane Transporter Activity
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