AMIGO2 and AMIGO3

Number of citations of the paper that reports this interaction (PubMedID 12629050)
35

Data Source:
HPRD (in vivo)

		AMIGO2	AMIGO3
Description		adhesion molecule with Ig like domain 2	adhesion molecule with Ig like domain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Membrane	Membrane
	Molecular Function	Protein Binding	Protein-containing Complex Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Brain Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Synapse Assembly	Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Nervous System Development Brain Development Negative Regulation Of Neuron Projection Development Positive Regulation Of Synapse Assembly
Pathways		RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Mood instability ( 31168069) Multisite chronic pain ( 31194737) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633)
Interacting Genes		4 interacting genes: AMIGO1 AMIGO3 CACNA1A TMED8	2 interacting genes: AMIGO1 AMIGO2
Entrez ID		347902	386724
HPRD ID		16483	16484
Ensembl ID		ENSG00000139211	ENSG00000176020
Uniprot IDs		Q86SJ2	Q86WK7
PDB IDs
Enriched GO Terms of Interacting Partners?		Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Synapse Assembly Positive Regulation Of Cell Junction Assembly Regulation Of Synapse Assembly Pericellular Basket Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Brain Development Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Regulation Of Synapse Organization Cellular Response To L-glutamate Neuronal Cell Body Calcium Ion Import Across Plasma Membrane Voltage-gated Calcium Channel Complex High Voltage-gated Calcium Channel Activity Calcium Ion Import Into Cytosol Cell-cell Adhesion Positive Regulation Of Cellular Component Biogenesis Response To L-glutamate Regulation Of Neuron Projection Development Neuronal Cell Body Membrane Axonal Fasciculation Neuron Projection Fasciculation Regulation Of Nervous System Development Positive Regulation Of Potassium Ion Transmembrane Transport Nervous System Development Voltage-gated Calcium Channel Activity Calcium Ion Import Positive Regulation Of Potassium Ion Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Synapse Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Cell Junction Assembly Regulation Of Synapse Assembly Regulation Of Multicellular Organismal Development Positive Regulation Of Developmental Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Pericellular Basket Brain Development Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Positive Regulation Of Multicellular Organismal Process Regulation Of Synapse Organization Cellular Response To L-glutamate Positive Regulation Of Cell Development Regulation Of Nervous System Development RSC-type Complex Cell-cell Adhesion Positive Regulation Of Cellular Component Biogenesis Regulation Of Developmental Process Regulation Of Cellular Component Organization Response To L-glutamate Axonal Fasciculation Neuron Projection Fasciculation Neuronal Cell Body Membrane Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Nucleotide-excision Repair Regulation Of Multicellular Organismal Process Nuclear Chromosome SWI/SNF Complex Positive Regulation Of Potassium Ion Transport Regulation Of G0 To G1 Transition Regulation Of Cell Development Transcription Elongation By RNA Polymerase II Positive Regulation Of Myoblast Differentiation Positive Regulation Of Cell Differentiation Potassium Channel Regulator Activity Cell Adhesion Neuron Recognition DNA-templated Transcription Elongation
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