DSCAML1 and MAGI3

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		DSCAML1	MAGI3
Gene Name		Down syndrome cell adhesion molecule like 1	membrane associated guanylate kinase, WW and PDZ domain containing 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane	Nucleus Plasma Membrane Tight Junction Membrane
	Molecular Function	Protein Homodimerization Activity	Guanylate Kinase Activity Frizzled Binding Protein Binding ATP Binding Protein Complex Scaffold
	Biological Process	Cell Fate Determination Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Axonogenesis Central Nervous System Development Brain Development Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Dendrite Self-avoidance	Apoptotic Process Viral Process Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Nucleotide Phosphorylation
Pathways		DSCAM interactions
Drugs
Diseases
GWAS		Menarche (age at onset) ( 23599027) Triglycerides ( 19074352)	Bulimia nervosa ( 23568457) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: MAGI2 MAGI3 PLCL2	14 interactors: ADRB1 BAI1 DSCAML1 FZD4 FZD7 GRIN2B LATS1 NRCAM PLXNB3 PTEN PTPRB TGFA TNK2 VANGL2
Entrez ID		57453	260425
HPRD ID		10921	11290
Ensembl ID		ENSG00000177103	ENSG00000081026
Uniprot IDs		Q8TD84	Q5TCQ9
PDB IDs		1VA9	3SOE
Enriched GO Terms of Interacting Partners?		Planar Cell Polarity Pathway Involved In Axis Elongation B-1a B Cell Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Receptor Binding B-1 B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway B Cell Proliferation Involved In Immune Response Negative Regulation Of Activin Receptor Signaling Pathway Glomerular Visceral Epithelial Cell Development Positive Regulation Of Phosphoprotein Phosphatase Activity Nerve Growth Factor Signaling Pathway Regulation Of Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Differentiation Regulation Of B Cell Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Receptor Internalization Mature B Cell Differentiation Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Activin Receptor Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Of Phosphatase Activity Regulation Of Receptor Internalization Non-canonical Wnt Signaling Pathway Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Synaptic Transmission, GABAergic Axis Elongation Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Protein Kinase B Signaling Cell Differentiation Involved In Kidney Development B Cell Proliferation Regulation Of Protein Phosphorylation Positive Regulation Of Dephosphorylation B Cell Activation Involved In Immune Response Negative Regulation Of Signal Transduction Receptor Clustering SMAD Protein Signal Transduction Negative Regulation Of Signaling Nucleotide Phosphorylation Glomerulus Development Positive Regulation Of Protein Binding Regulation Of Phosphorylation Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Phosphatase Activity B Cell Differentiation Regulation Of Peptidyl-serine Phosphorylation	Cell Morphogenesis Developmental Process Cell Morphogenesis Involved In Differentiation Neuron Differentiation Anatomical Structure Morphogenesis Cell Differentiation Generation Of Neurons System Development Neurogenesis Signaling Negative Regulation Of Cell Adhesion Cell Communication Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Multicellular Organismal Development Axonogenesis Anatomical Structure Development Neuron Development Axon Development Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Non-canonical Wnt Signaling Pathway Signal Transduction Nervous System Development Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Cell Projection Organization Locomotion Blood Vessel Morphogenesis Negative Regulation Of Cell-substrate Adhesion Regulation Of Phosphorylation Regulation Of Cellular Component Organization Neuron Projection Development Positive Regulation Of Phosphorylation Cardiovascular System Development Positive Regulation Of Protein Modification Process Blood Vessel Development Response To Stimulus Vasculature Development Cellular Response To Stimulus Regulation Of Postsynaptic Membrane Potential Wnt Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Multicellular Organismal Response To Stress Regulation Of Cell Adhesion Regulation Of Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			aberration akt1 akt3 amplifications beyond cbfb competitive confirming deaths deletions discovered erbb2 exome gata3 genomes malignancy map3k1 mexico million notably oestrogen pairs partner pik3ca rearrangements recurrent runx1 somatic vietnam
Tagcloud (Difference) ?			aberration akt1 akt3 amplifications beyond cbfb competitive confirming deaths deletions discovered erbb2 exome gata3 genomes malignancy map3k1 mexico million notably oestrogen pairs partner pik3ca rearrangements recurrent runx1 somatic vietnam
Tagcloud (Intersection) ?